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IL15 and STAT5B
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
87
Data Source:
BioGRID
(two hybrid)
IL15
STAT5B
Description
interleukin 15
signal transducer and activator of transcription 5B
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleoplasm
Cytoplasm
Endosome
Golgi Apparatus
Cytosol
Cell Surface
Nuclear Speck
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Cytokine Activity
Cytokine Receptor Binding
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Glucocorticoid Receptor Binding
Identical Protein Binding
Protein Dimerization Activity
Biological Process
Positive Regulation Of Cytokine Production
NK T Cell Proliferation
Inflammatory Response
Immune Response
Signal Transduction
Tyrosine Phosphorylation Of STAT Protein
Cell-cell Signaling
Aging
Positive Regulation Of Cell Population Proliferation
Skeletal Muscle Atrophy
Hyaluronan Metabolic Process
Macrophage Differentiation
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Natural Killer Cell Proliferation
Positive Regulation Of Natural Killer Cell Differentiation
Positive Regulation Of Tissue Remodeling
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
Neutrophil Activation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Extrathymic T Cell Selection
Regulation Of T Cell Differentiation
Cell Maturation
Lymph Node Development
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Defense Response To Virus By Host
Positive Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phagocytosis
Positive Regulation Of Immune Response
Cellular Response To Vitamin D
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Protein O-linked Glycosylation
Luteinization
Natural Killer Cell Differentiation
Regulation Of Transcription By RNA Polymerase II
Defense Response
Receptor Signaling Pathway Via JAK-STAT
Female Pregnancy
Lactation
Regulation Of Steroid Metabolic Process
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Lipid Storage
Regulation Of Epithelial Cell Differentiation
Response To Estradiol
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Natural Killer Cell Proliferation
Positive Regulation Of Natural Killer Cell Differentiation
Cellular Response To Hormone Stimulus
T Cell Differentiation In Thymus
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Cell Population Proliferation
Progesterone Metabolic Process
T Cell Homeostasis
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Development Of Secondary Female Sexual Characteristics
Development Of Secondary Male Sexual Characteristics
Peyer's Patch Development
Positive Regulation Of Inflammatory Response
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Response To Interleukin-2
Response To Interleukin-4
Response To Interleukin-15
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Mast Cell Migration
Pathways
Interleukin-15 signaling
Interleukin-15 signaling
Prolactin receptor signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signaling by Leptin
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Erythropoietin activates STAT5
STAT5 Activation
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
Cefazolin
Dasatinib
Diseases
GWAS
Insomnia (
29520036
)
Malaria (
31844061
)
Post-traumatic stress disorder symptoms in trauma-exposed soldiers (
30999091
)
Response to treatment for acute lymphoblastic leukemia (
19176441
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
31361310
34103634
32296059
)
Asthma (childhood onset) (
31036433
)
Body shape index (
34021172
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
27569725
28067908
23128233
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Paracentral lobule volume (
31530798
)
Ulcerative colitis (
28067908
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
7 interacting genes:
APP
IL15RA
IL2RB
IL2RG
POLR1H
STAT5B
TRAF3
62 interacting genes:
AFTPH
APP
CBL
CD247
CDKN1A
CENPJ
CHAF1A
CRK
CRKL
CTLA4
CXCR4
DMRTA1
EGFR
ELP2
EP300
EPOR
ERBB4
ETS1
ETS2
GHR
HAX1
HNRNPA2B1
IL15
IL2RA
IL2RB
IL7R
INSR
JAK2
JAK3
KIT
LGALS14
LMO4
MAPK1
MED25
MRPS6
NCOR2
NMI
NR3C1
PDGFRA
PDGFRB
PIK3R3
POU2F1
PPP2CA
PTPN1
PTPN11
PTPN2
PTPN6
RARA
RBBP4
SERTAD1
SHC1
SRC
STAC
STAP2
STAT1
STAT3
STAT5A
SUOX
TEK
TFG
TSSK3
USP2
Entrez ID
3600
6777
HPRD ID
02776
05037
Ensembl ID
ENSG00000164136
ENSG00000173757
Uniprot IDs
P40933
P51692
PDB IDs
2XQB
2Z3Q
2Z3R
4GS7
6MBW
6MBZ
Enriched GO Terms of Interacting Partners
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