IL2RG and SHB

Number of citations of the paper that reports this interaction (PubMedID 12200137)
6

Data Source:
HPRD (in vivo)

		IL2RG	SHB
Description		interleukin 2 receptor subunit gamma	SH2 domain containing adaptor protein B
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex	Nucleoplasm Cytosol Plasma Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity	Phosphotyrosine Residue Binding Protein Binding
	Biological Process	Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Positive Regulation Of Phagocytosis	Angiogenesis Apoptotic Process Signal Transduction Cell Differentiation
Pathways		Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling STAT3 nuclear events downstream of ALK signaling	VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway
Drugs		Denileukin diftitox Aldesleukin Resatorvid
Diseases
GWAS			Brain structure ( 20171287) Chronotype ( 30696823) Loneliness (linear analysis) ( 27629369) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		27 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 KRTAP10-8 KRTAP5-7 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2	28 interacting genes: ABL1 AR CRK EGFR EPS8 ERBB2 ERBB3 ERBB4 FGFR1 GRAP2 GRB2 IL2RB IL2RG JAK1 JAK3 KDR KIT LAMTOR5 LAT LCP2 MET PDGFRA PIK3R1 PLCG1 SLC39A1 SRC VAV1 ZAP70
Entrez ID		3561	6461
HPRD ID		02391	02635
Ensembl ID		ENSG00000147168	ENSG00000107338
Uniprot IDs		P31785	Q15464
PDB IDs		1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL
Enriched GO Terms of Interacting Partners?
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