APOD and LEPR

Number of citations of the paper that reports this interaction (PubMedID 11344130)
13

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		APOD	LEPR
Description		apolipoprotein D	leptin receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Cytosolic Ribosome Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region External Side Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Lipid Transporter Activity Protein Binding Cholesterol Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Leptin Receptor Activity
	Biological Process	Response To Reactive Oxygen Species Angiogenesis Glucose Metabolic Process Lipid Metabolic Process Lipid Transport Brain Development Aging Response To Xenobiotic Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Tissue Regeneration Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of T Cell Migration	Angiogenesis Positive Regulation Of Protein Phosphorylation Glycogen Metabolic Process Energy Reserve Metabolic Process Phagocytosis Cell Surface Receptor Signaling Pathway Multicellular Organism Development Cholesterol Metabolic Process Negative Regulation Of Autophagy Glial Cell Proliferation Cytokine-mediated Signaling Pathway Sexual Reproduction T Cell Differentiation Leptin-mediated Signaling Pathway Glucose Homeostasis Response To Leptin Negative Regulation Of Gluconeogenesis Regulation Of Bone Remodeling Regulation Of Transport Negative Regulation Of Hydrolase Activity Regulation Of Feeding Behavior Energy Homeostasis Bone Growth Positive Regulation Of Cold-induced Thermogenesis Transport Across Blood-brain Barrier
Pathways		Transport of fatty acids NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs		Vitamin A Copper	Leptin Metreleptin
Diseases
GWAS		HDL cholesterol levels ( 32203549)	Adult body size ( 32376654) Age at voice drop ( 27182965) Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Blood protein levels ( 30072576 29875488 28240269) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) BMI at 3 months old ( 31575865) BMI at 6 months old ( 31575865) BMI at 8 months old ( 31575865) BMI at adiposity peak ( 31840077) Body size at age 10 ( 32376654) C-reactive protein ( 19567438 18439548 23844046 22939635) C-reactive protein levels ( 33339817 30388399 21300955) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Eosinophil percentage of white cells ( 32888494) Fasting plasma glucose (childhood) ( 25223902) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Hip circumference ( 28552196) Iron status biomarkers (iron levels) ( 33536631) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Metabolic traits ( 19060910) Molybdenum levels ( 26025379) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Nonalcoholic steatohepatitis ( 32298765) Obesity (early onset extreme) ( 23563609) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum alkaline phosphatase levels ( 33547301) Soluble leptin receptor levels ( 20167575) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)
Interacting Genes		51 interacting genes: AIG1 APH1A APOA2 AQP9 ATP6V0B ATP6V0E1 BCL2L13 BIK CD53 CD79A CLDN7 CLEC10A CPLX4 CREB3 CREB3L1 ERGIC3 EVI2B FAM209A FFAR2 FKBP7 FPR2 GDAP1 GJA8 GORAB GPR151 GPR42 GPX8 KCNJ6 KIR2DL3 LEPR LMNA MFF MGST3 MTERF2 MTIF3 NCAPH2 PDZK1IP1 POLR2M RHBDL1 SHBG SIGLECL1 SLC10A6 SLC35C2 TEX29 TMEM237 TMEM31 TMEM45B TMEM52B TMEM79 VAPA VSIR	16 interacting genes: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 XRN1
Entrez ID		347	3953
HPRD ID		00134	03001
Ensembl ID		ENSG00000189058	ENSG00000116678
Uniprot IDs		P05090	P48357 Q4G138
PDB IDs		2APD 2HZQ 2HZR	3V6O 6E2P
Enriched GO Terms of Interacting Partners?
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