LEPR and SNX2

Number of citations of the paper that reports this interaction (PubMedID 9819414)
86

Data Source:
HPRD (in vitro, in vivo)

		LEPR	SNX2
Description		leptin receptor	sorting nexin 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region External Side Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Receptor Complex	Cytoplasm Lysosome Endosome Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Protein-containing Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Leptin Receptor Activity	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Angiogenesis Positive Regulation Of Protein Phosphorylation Glycogen Metabolic Process Energy Reserve Metabolic Process Phagocytosis Cell Surface Receptor Signaling Pathway Multicellular Organism Development Cholesterol Metabolic Process Negative Regulation Of Autophagy Glial Cell Proliferation Cytokine-mediated Signaling Pathway Sexual Reproduction T Cell Differentiation Leptin-mediated Signaling Pathway Glucose Homeostasis Response To Leptin Negative Regulation Of Gluconeogenesis Regulation Of Bone Remodeling Regulation Of Transport Negative Regulation Of Hydrolase Activity Regulation Of Feeding Behavior Energy Homeostasis Bone Growth Positive Regulation Of Cold-induced Thermogenesis Transport Across Blood-brain Barrier	Intracellular Protein Transport Endocytosis Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Lamellipodium Morphogenesis
Pathways			Golgi Associated Vesicle Biogenesis
Drugs		Leptin Metreleptin
Diseases
GWAS		Adult body size ( 32376654) Age at voice drop ( 27182965) Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Blood protein levels ( 30072576 29875488 28240269) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) BMI at 3 months old ( 31575865) BMI at 6 months old ( 31575865) BMI at 8 months old ( 31575865) BMI at adiposity peak ( 31840077) Body size at age 10 ( 32376654) C-reactive protein ( 19567438 18439548 23844046 22939635) C-reactive protein levels ( 33339817 30388399 21300955) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Eosinophil percentage of white cells ( 32888494) Fasting plasma glucose (childhood) ( 25223902) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Hip circumference ( 28552196) Iron status biomarkers (iron levels) ( 33536631) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Metabolic traits ( 19060910) Molybdenum levels ( 26025379) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Nonalcoholic steatohepatitis ( 32298765) Obesity (early onset extreme) ( 23563609) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum alkaline phosphatase levels ( 33547301) Soluble leptin receptor levels ( 20167575) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Plateletcrit ( 32888494) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		16 interacting genes: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 XRN1	28 interacting genes: ACVR1B ACVR2B ARL6IP1 C1orf122 CENPQ CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET MTIF3 NFYC PAK6 PDGFRA PDGFRB PLIN3 PNKP SNX1 SNX32 SNX4 SNX5 SNX6 TMEM239 YIF1A ZNF202
Entrez ID		3953	6643
HPRD ID		03001	09332
Ensembl ID		ENSG00000116678	ENSG00000205302
Uniprot IDs		P48357 Q4G138	O60749
PDB IDs		3V6O 6E2P
Enriched GO Terms of Interacting Partners?
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