IFNGR2 and SFT2D2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IFNGR2	SFT2D2
Description		interferon gamma receptor 2	SFT2 domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane	Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding	Molecular_function Protein Binding
	Biological Process	Microglial Cell Activation Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Positive Regulation Of NMDA Glutamate Receptor Activity	Biological_process Protein Transport Vesicle-mediated Transport
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS
Drugs		Interferon gamma-1b
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 23128233) Diverticular disease ( 30177863) Educational attainment ( 25201988) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 30423114 24390342)	Alzheimer's disease ( 30636644) LDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		46 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CCT8 CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 GRIK1 HCRTR1 HLCS IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM199 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 ZDHHC24	29 interacting genes: AQP6 ATP5PF BNIP2 CREB3 ELOVL4 GPR152 HIBADH HSD17B11 HSD17B13 IFNGR2 INPP5K LMNA MOB2 NDRG4 PBX3 PLIN2 PLIN3 REEP2 REEP4 SLC10A1 SLC10A6 SLC30A8 STOM TAS2R5 TCP11X2 TIMM44 TMEM143 TMEM14B TMEM51
Entrez ID		3460	375035
HPRD ID		00956	14192
Ensembl ID		ENSG00000159128	ENSG00000213064
Uniprot IDs		A8K881 E7EUY1 P38484	O95562
PDB IDs		5EH1 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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