SLC9A6 and IFNGR1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SLC9A6	IFNGR1
Description		solute carrier family 9 member A6	interferon gamma receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Recycling Endosome Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Ion Transport Axon Extension Neuron Projection Morphogenesis Regulation Of Intracellular PH Potassium Ion Transmembrane Transport Dendrite Extension Anion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport	Microglial Cell Activation Signal Transduction Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Astrocyte Activation Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation
Pathways		Sodium/Proton exchangers Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH)	Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS
Drugs			Interferon gamma-1b
Diseases
GWAS			Behcet's disease ( 33393726) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cognitive performance (processing speed) ( 31598132)
Interacting Genes		2 interacting genes: CFTR IFNGR1	17 interacting genes: AHI1 AQP6 CANX IFNG IFNGR2 JAK1 JAK2 NINJ2 PTPN11 RAC1 RUSF1 SLC9A6 SOCS1 STAT1 STIM1 TMEM100 TMEM237
Entrez ID		10479	3459
HPRD ID		02208	00127
Ensembl ID		ENSG00000198689	ENSG00000027697
Uniprot IDs		A0A1B0GV11 Q92581	A0A0S2Z3Y2 A0A2R8Y4U4 P15260
PDB IDs			1FG9 1FYH 1JRH 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?