HSPE1 and APLP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HSPE1	APLP1
Description		heat shock protein family E (Hsp10) member 1	amyloid beta precursor like protein 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome	Basement Membrane Nucleoplasm Golgi Apparatus Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Protein Binding ATP Binding Metal Ion Binding Unfolded Protein Binding Chaperone Binding	Protein Binding Heparin Binding Alpha-2A Adrenergic Receptor Binding Alpha-2B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Identical Protein Binding Transition Metal Ion Binding
	Biological Process	Osteoblast Differentiation Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Chaperone Cofactor-dependent Protein Refolding	Endocytosis Apoptotic Process Cell Adhesion Nervous System Development Animal Organ Morphogenesis Extracellular Matrix Organization Forebrain Development Cellular Response To Norepinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways		RHOG GTPase cycle
Drugs		Phenethyl Isothiocyanate	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Schizophrenia ( 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		16 interacting genes: ALDH2 APLP1 CASP3 CRMP1 EEF1A1 ERG28 GBP2 HSPD1 LRIF1 NTAQ1 SAT1 SELENOM STK3 TLE1 UNC119 ZHX1	43 interacting genes: ANXA7 APBB1 CDK4 CDKN1A CDKN2C CRCT1 CSNK2B DAB1 DAB2 EEF1A1 EIF2S2 ERBB2 GDF9 GSTM4 HAP1 HLA-DQA1 HSPE1 ING5 KAT5 LRIF1 MPHOSPH6 NACA PCDHA4 PHF10 PIN1 PNP PRNP RAP1B RBM48 RCC1 SAT1 SETDB1 SMN1 SNCA STX5 TCF21 TK1 TMSB4X TOE1 TSC22D1 UTP14A VIM ZNF24
Entrez ID		3336	333
HPRD ID		02535	00102
Ensembl ID		ENSG00000115541	ENSG00000105290
Uniprot IDs		A0A384N6A4 P61604	P51693
PDB IDs		4PJ1 6HT7 6MRC 6MRD	3PMR 3Q7G 3Q7L 3QMK 4RD9 4RDA
Enriched GO Terms of Interacting Partners?
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