PRAP1 and HSPA6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PRAP1	HSPA6
Description		proline rich acidic protein 1	heat shock protein family A (Hsp70) member 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Triglyceride Binding	Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding
	Biological Process	Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Apoptotic Process Cellular Response To X-ray Deactivation Of Mitotic Spindle Assembly Checkpoint Positive Regulation Of Intestinal Lipid Absorption Positive Regulation Of Triglyceride Transport Positive Regulation Of Phospholipid Transport	Response To Unfolded Protein Vesicle-mediated Transport Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Cellular Heat Acclimation
Pathways			Regulation of HSF1-mediated heat shock response Neutrophil degranulation
Drugs
Diseases
GWAS		Nonunion in individuals with fractures ( 30680360)	Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 28067908 23128233) Offspring birth weight ( 31043758) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		11 interacting genes: AHNAK2 ASPH CEP19 GRB2 HSPA6 MEOX2 MRFAP1 SGTA SGTB UBQLN1 UBQLN2	18 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FCGR2B FLNA KRT222 LGALS7 LGALS7B MPZ PPIB PRAP1 RPA1 TERF1
Entrez ID		118471	3310
HPRD ID		17898	00775
Ensembl ID		ENSG00000165828	ENSG00000173110
Uniprot IDs		A6XND8 Q96NZ9	A0A384NKX5 B3KSM6 P17066
PDB IDs			3FE1
Enriched GO Terms of Interacting Partners?
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