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HES1 and PTK2
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
136
Data Source:
BioGRID
(two hybrid)
HES1
PTK2
Description
hes family bHLH transcription factor 1
protein tyrosine kinase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Protein-containing Complex
Stress Fiber
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Cell Cortex
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ciliary Basal Body
Dendritic Spine
Intracellular Membrane-bounded Organelle
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
HLH Domain Binding
Sequence-specific DNA Binding
Chaperone Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
N-box Binding
Sequence-specific Double-stranded DNA Binding
Actin Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
JUN Kinase Binding
Protein Kinase Binding
Protein Phosphatase Binding
SH2 Domain Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Liver Development
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Regulation Of Transcription By RNA Polymerase II
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
Nervous System Development
Positive Regulation Of Cell Population Proliferation
Anterior/posterior Pattern Specification
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Adenohypophysis Development
Lung Development
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Pancreas Development
Somatic Stem Cell Population Maintenance
Ascending Aorta Morphogenesis
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Fat Cell Differentiation
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Cell Maturation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Inner Ear Receptor Cell Stereocilium Organization
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Protein-containing Complex Assembly
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Establishment Of Epithelial Cell Polarity
Vascular Associated Smooth Muscle Cell Development
Neuronal Stem Cell Population Maintenance
Negative Regulation Of Cell Fate Determination
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Angiogenesis
Placenta Development
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Heart Morphogenesis
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Axon Guidance
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Endothelial Cell Migration
Regulation Of Epithelial Cell Migration
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Cell Migration
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Cell-cell Adhesion
Establishment Of Cell Polarity
Cell Differentiation
Regulation Of Cell Adhesion
Positive Regulation Of Cell Migration
Regulation Of Cell Adhesion Mediated By Integrin
Detection Of Muscle Stretch
Netrin-activated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Regulation Of GTPase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Regulation Of Osteoblast Differentiation
Positive Regulation Of Protein Kinase Activity
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Cell Motility
Regulation Of Cytoskeleton Organization
Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Growth Hormone Receptor Signaling Pathway
Positive Regulation Of Wound Healing
Positive Regulation Of Macrophage Proliferation
Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Anoikis
Pathways
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Apoptotic cleavage of cellular proteins
Regulation of actin dynamics for phagocytic cup formation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth
Signal regulatory protein family interactions
EPHB-mediated forward signaling
EPHB-mediated forward signaling
DCC mediated attractive signaling
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MET activates PTK2 signaling
Extra-nuclear estrogen signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
FCGR3A-mediated phagocytosis
Drugs
Endostatin
7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE
2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE
Fostamatinib
Diseases
GWAS
Alcoholic chronic pancreatitis (
28754779
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Thyroid stimulating hormone levels (
30367059
32769997
)
Acute graft versus host disease in bone marrow transplantation (recipient effect) (
27595289
)
Apolipoprotein B levels (
32203549
)
Atrial fibrillation (
30061737
29892015
)
Deep white matter hyperintensities (
32517579
)
Diastolic blood pressure (
30224653
)
LDL cholesterol levels (
32203549
)
Mean corpuscular hemoglobin (
27863252
)
Mood instability (
31168069
)
Multisite chronic pain (
33830993
)
Nickel levels (
26025379
)
PR interval (
32439900
)
Red cell distribution width (
32888494
)
Response to interferon beta therapy (
21502966
)
Smoking status (ever vs never smokers) (
30643258
)
Interacting Genes
35 interacting genes:
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY1
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NHLH2
NR4A1
NUDT3
PRKCA
PTK2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
114 interacting genes:
ACTN1
APP
ARHGAP26
ASAP1
ATG12
BBS10
BCAR1
BIN1
BMX
CCR5
CD47
CD79B
CIB1
CRK
CSK
CSPG4
CXCR4
DCC
DDX39A
DEF6
DLGAP3
DNM2
DOK4
EEF1G
EFS
EGFR
EPHA2
EPHB2
EPS8L2
ERBB2
ERBB3
EZR
F13A1
FBP1
FGR
FLT1
FLT4
FYN
GIT1
GRB2
GRB7
GSK3B
GZMB
HES1
IGHM
INSR
IRS1
ITGAV
ITGB1
ITGB2
ITGB3
ITGB4
ITGB5
JAK2
KCNB1
KCNMA1
LCK
LPXN
LYN
MAPK8IP3
MDM2
MICAL1
NACAD
NASP
NCK1
NCK2
NEDD8
NEDD9
NEO1
PDGFRB
PIAS1
PIK3R1
PIK3R3
PKD1
PLCG1
PPP1CB
PTEN
PTK2B
PTPN11
PTPN12
PTPRH
PXN
RAC1
RB1CC1
RET
RIPK1
ROCK1
SAE1
SELE
SH2D1A
SH2D1B
SHC1
SOCS1
SOCS2
SOCS3
SORBS1
SRC
SRPK1
STAT1
SYK
TGFB1I1
TLN1
TNFRSF1A
TNS1
TNS3
TP53
TRIM15
TRIO
TRIP6
TSC2
VCL
YES1
ZFYVE21
ZNF331
Entrez ID
3280
5747
HPRD ID
00770
02859
Ensembl ID
ENSG00000114315
ENSG00000169398
Uniprot IDs
Q14469
Q05397
Q59GM6
Q59GN8
Q658W2
PDB IDs
2MH3
1K04
1K05
1MP8
1OW6
1OW7
1OW8
2ETM
2IJM
3B71
3BZ3
3PXK
3S9O
4EBV
4EBW
4GU6
4GU9
4I4E
4I4F
4K8A
4K9Y
4KAB
4KAO
4NY0
4Q9S
6I8Z
6LES
6PW8
6YOJ
6YQ1
6YR9
6YT6
6YVS
6YVY
6YXV
Enriched GO Terms of Interacting Partners
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