HES1 and NHLH2

Number of citations of the paper that reports this interaction (PubMedID 21573214)
24

Data Source:
BioGRID (pull down, pull down, genetic interference)

		HES1	NHLH2
Description		hes family bHLH transcription factor 1	nescient helix-loop-helix 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein-containing Complex	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding HLH Domain Binding Sequence-specific DNA Binding Chaperone Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding N-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Cell Adhesion Notch Signaling Pathway Smoothened Signaling Pathway Nervous System Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Cell Migration Telencephalon Development Midbrain-hindbrain Boundary Morphogenesis Oculomotor Nerve Development Trochlear Nerve Development Hindbrain Morphogenesis Forebrain Radial Glial Cell Differentiation Adenohypophysis Development Lung Development Positive Regulation Of BMP Signaling Pathway Midbrain Development Pancreas Development Somatic Stem Cell Population Maintenance Ascending Aorta Morphogenesis Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Fat Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitotic Cell Cycle, Embryonic Lateral Inhibition Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Maturation Thymus Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Artery Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Inner Ear Receptor Cell Stereocilium Organization Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Glial Cell Proliferation Ventricular Septum Morphogenesis Ureteric Bud Morphogenesis Labyrinthine Layer Blood Vessel Development Common Bile Duct Development Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Pharyngeal Arch Artery Morphogenesis Protein-containing Complex Assembly Glomerulus Vasculature Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Interstitial Fibroblast Development Metanephric Nephron Tubule Morphogenesis Cochlea Development Establishment Of Epithelial Cell Polarity Vascular Associated Smooth Muscle Cell Development Neuronal Stem Cell Population Maintenance Negative Regulation Of Cell Fate Determination Negative Regulation Of Pancreatic A Cell Differentiation Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Central Nervous System Development Peripheral Nervous System Development Male Gonad Development Cell Migration In Hindbrain Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Ovulation Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Male Mating Behavior
Pathways		Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Thyroid stimulating hormone levels ( 30367059 32769997)	Electrocardiographic traits (multivariate) ( 32602732) Heart rate variability traits (SDNN) ( 28610988) Metabolite levels ( 23823483)
Interacting Genes		35 interacting genes: APCS APH1A ASGR2 CSNK1E FANCA FANCE FANCF FANCG FANCL FHL1 FOXG1 GAPDH HDAC6 HES6 HEY1 HEY2 HMGB1 HMGCL ID1 ID2 ID3 ID4 JAK2 LTBR NHLH2 NR4A1 NUDT3 PRKCA PTK2 SIRT1 STAT3 TLE1 TLE2 UBQLN1 YWHAB	7 interacting genes: HES1 KCNIP1 LMO3 MYF5 TAF1D TCF12 TCF4
Entrez ID		3280	4808
HPRD ID		00770	01213
Ensembl ID		ENSG00000114315	ENSG00000177551
Uniprot IDs		Q14469	A1PLF1 Q02577
PDB IDs		2MH3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?