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HES1 and FANCL
Number of citations of the paper that reports this interaction (PubMedID
18550849
)
29
Data Source:
BioGRID
(two hybrid, affinity chromatography technology, affinity chromatography technology)
HPRD
(two hybrid, in vivo)
HES1
FANCL
Description
hes family bHLH transcription factor 1
FA complementation group L
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Protein-containing Complex
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Nuclear Body
Intracellular Membrane-bounded Organelle
Fanconi Anaemia Nuclear Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
HLH Domain Binding
Sequence-specific DNA Binding
Chaperone Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
N-box Binding
Sequence-specific Double-stranded DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Liver Development
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Regulation Of Transcription By RNA Polymerase II
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
Nervous System Development
Positive Regulation Of Cell Population Proliferation
Anterior/posterior Pattern Specification
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Adenohypophysis Development
Lung Development
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Pancreas Development
Somatic Stem Cell Population Maintenance
Ascending Aorta Morphogenesis
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Fat Cell Differentiation
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Cell Maturation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Inner Ear Receptor Cell Stereocilium Organization
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Protein-containing Complex Assembly
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Establishment Of Epithelial Cell Polarity
Vascular Associated Smooth Muscle Cell Development
Neuronal Stem Cell Population Maintenance
Negative Regulation Of Cell Fate Determination
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
DNA Repair
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Gamete Generation
Interstrand Cross-link Repair
Regulation Of Cell Population Proliferation
Pathways
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Fanconi Anemia Pathway
Drugs
Diseases
GWAS
Alcoholic chronic pancreatitis (
28754779
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Thyroid stimulating hormone levels (
30367059
32769997
)
Adult body size (
32376654
)
Age at first sexual intercourse (
34211149
)
Autism spectrum disorder or schizophrenia (
28540026
)
Body mass index (
31453325
20935630
)
Body mass index variance (
31453325
)
Body size at age 10 (
32376654
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Childhood absence epilepsy (
30531953
)
Chronotype (
30696823
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Daytime nap (
33568662
)
Epilepsy (
25087078
30531953
)
Feeling miserable (
29500382
)
Fish- and plant-related diet (
32066663
)
Fruit consumption (
32066663
)
Generalized epilepsy (
30531953
)
HDL cholesterol levels (
32203549
)
Hirschsprung disease (
27702942
)
Initial pursuit acceleration (
29064472
)
Irritable mood (
29500382
)
Obesity (
23563607
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Response to selective serotonin reuptake inhibitors and depression (
27622933
)
Schizophrenia (
25056061
29483656
)
Smoking status (ever vs never smokers) (
30643258
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Tea consumption (
31046077
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
30718926
)
Waist circumference (
25673412
)
Waist-hip index (
34021172
)
Waist-hip ratio (
25673412
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
35 interacting genes:
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY1
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NHLH2
NR4A1
NUDT3
PRKCA
PTK2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
48 interacting genes:
ACVR1
ANTKMT
BMPR1B
C19orf54
CADPS
CERCAM
CHCHD3
CTBP1
CTDSP1
CYB5R2
DDAH2
DOCK8
EIF4ENIF1
FAAP100
FANCB
FANCD2
FANCF
FANCI
GATA1
GGN
GRN
HDHD3
HES1
HOXD4
ID2
IHO1
IKZF3
KIFC3
KRTAP11-1
KRTAP13-2
KRTAP19-6
LZTS2
METTL15
MORN3
PCNA
RBM45
RIMBP3
RNF11
SCNM1
SNF8
SSX2IP
TFCP2
TGFBR1
UBE2T
UBE2W
UFSP1
YPEL3
ZNF581
Entrez ID
3280
55120
HPRD ID
00770
06997
Ensembl ID
ENSG00000114315
ENSG00000115392
Uniprot IDs
Q14469
Q9NW38
PDB IDs
2MH3
3ZQS
4CCG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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