HOXA10 and GMNN

Number of citations of the paper that reports this interaction (PubMedID 14973489)
76

Data Source:
HPRD (in vitro)

		HOXA10	GMNN
Description		homeobox A10	geminin DNA replication inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Histone Deacetylase Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Spermatogenesis Single Fertilization Male Gonad Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Uterus Development	Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication
Pathways			CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex
Drugs		Calcitriol
Diseases
GWAS		Dental caries ( 23259602) Hypertension ( 31879980 30487518) Mean arterial pressure ( 30487518) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Metabolite levels ( 23823483)
Interacting Genes		16 interacting genes: CREBBP EMX1 EP300 FOXO1 GMNN GNG13 HMGB1 MAD1L1 MEIS1 NAB2 PBX1 POLR3D PTPN6 SIRT2 SNAPC1 SPI1	34 interacting genes: ARNT AURKA CASP3 CCDC146 CDC20 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 SAPCD2 SCMH1 SHANK2 SIX3 SMARCA4 ZNF250 ZNF439
Entrez ID		3206	51053
HPRD ID		00845	06783
Ensembl ID		ENSG00000253293	ENSG00000112312
Uniprot IDs		P31260	A0A024QZY7 O75496
PDB IDs			1T6F 1UII 2LP0 2WVR 4BRY
Enriched GO Terms of Interacting Partners?
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