HMMR and TPX2

Number of citations of the paper that reports this interaction (PubMedID 22110403)
42

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		HMMR	TPX2
Description		hyaluronan mediated motility receptor	TPX2 microtubule nucleation factor
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane	Spindle Pole Nucleus Nucleoplasm Spindle Cytosol Nuclear Microtubule Microtubule Cytoskeleton Axon Hillock Intercellular Bridge Mitotic Spindle
	Molecular Function	Protein Binding Hyaluronic Acid Binding	Protein Binding Microtubule Binding Protein Kinase Binding Protein Kinase Activator Activity Importin-alpha Family Protein Binding
	Biological Process		Mitotic Cell Cycle Apoptotic Process Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization Mitotic Spindle Assembly
Pathways		Hyaluronan uptake and degradation AURKA Activation by TPX2	Regulation of TP53 Activity through Phosphorylation AURKA Activation by TPX2
Drugs		Hyaluronic acid
Diseases
GWAS		Metabolite levels ( 23823483)	Brain morphology (MOSTest) ( 32665545) Immature fraction of reticulocytes ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Prudent dietary pattern ( 28644415)
Interacting Genes		16 interacting genes: ACTB BACH1 CALM1 CD44 CDH13 GREB1 IL24 ITIH5 MAPK3 MORN4 NAT2 SVIL THRSP TPX2 TRIM54 TUBB2A	8 interacting genes: AURKA CDK6 GOLGA2 HMMR NAP1L1 SIAH2 SUMO2 THAP11
Entrez ID		3161	22974
HPRD ID		02963	05802
Ensembl ID		ENSG00000072571	ENSG00000088325
Uniprot IDs		O75330	Q643R0 Q9ULW0
PDB IDs			1OL5 3E5A 3HA6 4C3P 5LXM 6BJC 6VPG 6VPH 6VPI 6VPJ 6VPL 6VPM 6XKA
Enriched GO Terms of Interacting Partners?
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