TPX2 and NAP1L1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		TPX2	NAP1L1
Description		TPX2 microtubule nucleation factor	nucleosome assembly protein 1 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Spindle Cytosol Nuclear Microtubule Microtubule Cytoskeleton Axon Hillock Intercellular Bridge Mitotic Spindle	Chromatin Nucleus Cytoplasm Membrane Melanosome
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding Protein Kinase Activator Activity Importin-alpha Family Protein Binding	Chromatin Binding RNA Binding Protein Binding Histone Binding
	Biological Process	Mitotic Cell Cycle Apoptotic Process Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization Mitotic Spindle Assembly	DNA Replication Nucleosome Assembly Positive Regulation Of Cell Population Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Regulation of TP53 Activity through Phosphorylation AURKA Activation by TPX2
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Immature fraction of reticulocytes ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Prudent dietary pattern ( 28644415)	Obesity-related traits ( 23251661) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189)
Interacting Genes		8 interacting genes: AURKA CDK6 GOLGA2 HMMR NAP1L1 SIAH2 SUMO2 THAP11	37 interacting genes: ANKRD23 C1QTNF9 CDK3 CES2 CHORDC1 CREBBP CSNK2A1 CSNK2B DLST EP300 ERCC6 FSD1 GAS2L2 H1-1 H3C1 H4C1 HBA1 HMGB2 HSPB1 KCNMB3 LINC01554 MED10 MTIF2 MTNR1A NAP1L2 NR2F6 OGT POT1 RPL23A RPS15 SP1 SUMO2 TERF1 TP53 TPX2 UBQLN2 ZDHHC17
Entrez ID		22974	4673
HPRD ID		05802	01248
Ensembl ID		ENSG00000088325	ENSG00000187109
Uniprot IDs		Q643R0 Q9ULW0	A0A024RBB7 B7Z2V4 F5H4R6 F8W543 P55209 Q9H2B0
PDB IDs		1OL5 3E5A 3HA6 4C3P 5LXM 6BJC 6VPG 6VPH 6VPI 6VPJ 6VPL 6VPM 6XKA
Enriched GO Terms of Interacting Partners?
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