RASGRF1 and GRK2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		RASGRF1	GRK2
Description		Ras protein specific guanine nucleotide releasing factor 1	G protein-coupled receptor kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Growth Cone Neuron Projection	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding	G Protein-coupled Receptor Binding Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Long-term Memory Cell Population Proliferation Neuron Projection Development Response To Endoplasmic Reticulum Stress Regulation Of Rac Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Activation Of GTPase Activity Regulation Of NMDA Receptor Activity	Regulation Of The Force Of Heart Contraction Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Regulation Of Signal Transduction Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Viral Entry Into Host Cell Cardiac Muscle Contraction Negative Regulation Of Relaxation Of Smooth Muscle
Pathways		Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade	Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis
Drugs			ATP
Diseases
GWAS		Adult body size ( 32376654) Bronchopulmonary dysplasia ( 23897914) Hand grip strength ( 29691431) High myopia ( 32428537) Myopia ( 27182965) Pancreatic beta-cell glucose sensitivity ( 32944759) Refractive error ( 23396134 32231278 20835236) RR interval (heart rate) ( 20031603) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		19 interacting genes: CEBPA EHD4 GRIN2B GRK2 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 SRC SRPK2 TNK2 USP8 YWHAB YWHAE	51 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 ARRB2 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 ERBB2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB2 GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2
Entrez ID		5923	156
HPRD ID		07362	00182
Ensembl ID		ENSG00000058335	ENSG00000173020
Uniprot IDs		A8K270 Q13972 Q8IUU5	A0A0S2Z392 P25098
PDB IDs			1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y 6U7C 7K7L 7K7Z
Enriched GO Terms of Interacting Partners?
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