GZMA and HDC

Number of citations of the paper that reports this interaction (PubMedID 19059912)
25

		GZMA	HDC
Description		granzyme A	histidine decarboxylase
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleus	Cytoplasm Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Protein Homodimerization Activity	Histidine Decarboxylase Activity Protein Binding Carboxy-lyase Activity Pyridoxal Phosphate Binding
	Biological Process	Apoptotic Process Immune Response Response To Bacterium Cytolysis Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Process	Histamine Biosynthetic Process Histidine Metabolic Process Histidine Catabolic Process Catecholamine Biosynthetic Process
Pathways			Histidine catabolism
Drugs			Pyridoxal phosphate Histidine
Diseases
GWAS			Basophil count ( 32888494) Lung function (FEV1/FVC) ( 30061609)
Interacting Genes		19 interacting genes: ACTG1 APEX1 GOLGA2 H1-1 H2BC21 HDC HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 NFIX PCP4 SET XRCC5 XRCC6	2 interacting genes: DTX2 GZMA
Entrez ID		3001	3067
HPRD ID		00771	00817
Ensembl ID		ENSG00000145649	ENSG00000140287
Uniprot IDs		P12544	P19113
PDB IDs		1HF1 1OP8 1ORF	4E1O
Enriched GO Terms of Interacting Partners?
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