GYS1 and TFAP2D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GYS1	TFAP2D
Description		glycogen synthase 1	transcription factor AP-2 delta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Inclusion Body	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Glycogen (starch) Synthase Activity Protein Binding Glucose Binding Protein Kinase Binding Glycogen Synthase Activity, Transferring Glucose-1-phosphate	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Glycogen Biosynthetic Process Heart Development	Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development Inferior Colliculus Development
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage disease type XV (GYG1) Glycogen storage disease type 0 (muscle GYS1)	Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 29273807) Breast size ( 22747683) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Fruit consumption ( 32066663) Hand grip strength ( 29691431) Overweight status ( 25133637) Parahippocampal gyrus volume ( 31530798) Refractive error ( 32231278) Response to citalopram or escitalopram in depression ( 27622933) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcutaneous adipose tissue ( 29178545) Systolic blood pressure ( 28135244) Western dietary pattern ( 28644415)
Interacting Genes		43 interacting genes: AIMP2 APP BEND7 CCDC33 CDCA8 CLVS2 CRX CSNK2A1 EFHC2 FAM228A GSK3B GYG1 GYG2 HOXB6 HOXC8 IHO1 INCA1 KATNBL1 KLF1 KLF4 MAPKAPK5 MEOX1 NDUFB7 NHLRC1 PCYT1A PINX1 PLAGL2 PNMA5 PRKACA RBM48 SNIP1 SORBS3 SUMO2 TFAP2D TLE5 WASHC1 ZBTB33 ZNF212 ZNF326 ZNF474 ZNF552 ZNF620 ZNF774	64 interacting genes: ADAM12 ADAMTSL4 AGR2 AKAP8L BAG4 CAMK2A CARD10 CDPF1 CEP76 CNFN CSNK2B CYSRT1 FAM166B FAM168A GUCD1 GYS1 HOXD12 IKZF3 INCA1 KLHL20 KPRP KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-3 KRTAP15-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP9-2 KRTAP9-3 MLH1 OIP5 PITX1 PLEKHG4 PRR22 PSMB4 RAD54L2 SIVA1 SLAIN1 SPRY1 SSC4D TEPSIN TEX37 TLE5 TNS2 TRAF1 TRIM42 TSC1 USP54 VPS37C ZBTB32 ZMYND12
Entrez ID		2997	83741
HPRD ID		00721	11627
Ensembl ID		ENSG00000104812	ENSG00000008197
Uniprot IDs		P13807	Q7Z6R9
PDB IDs
Enriched GO Terms of Interacting Partners?
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