PRICKLE4 and GNE

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid, two hybrid)

		PRICKLE4	GNE
Description		prickle planar cell polarity protein 4	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Adherens Junction Z Disc Filamentous Actin	Cytoplasm Cytosol
	Molecular Function	Molecular_function Actin Binding Zinc Ion Binding Muscle Alpha-actinin Binding	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding ATP Binding UDP-N-acetylglucosamine 2-epimerase Activity N-acylmannosamine Kinase Activity Metal Ion Binding
	Biological Process	Heart Development Biological_process Actin Cytoskeleton Organization Muscle Structure Development	N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process N-acetylneuraminate Metabolic Process Cell Adhesion Carbohydrate Phosphorylation
Pathways			Sialic acid metabolism Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)
Interacting Genes		10 interacting genes: AGXT CNTN4 GNE HOXA1 MTDH NEK6 OTX1 PLEKHN1 ZNF417 ZNF587	66 interacting genes: ADAMTSL4 C22orf39 CFP CRMP1 CYSRT1 ECM1 EGFL7 GRN GTPBP3 HOXA1 KIAA1549 KPRP KRT31 KRT34 KRT40 KRT83 KRT85 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MGAT5B NBPF19 NID2 NOTCH2NLA PLA2G10 PRICKLE4 RIF1 SIGMAR1 SPRY1 SPRY2 SPRY3 SSC4D TRIM27 TRIM42 TRIP6 TSPAN4 VWC2 WDR83 WWOX ZBTB16
Entrez ID		29964	10020
HPRD ID		12884	04825
Ensembl ID		ENSG00000278224	ENSG00000159921
Uniprot IDs		Q2TBC4	Q9Y223
PDB IDs			2YHW 2YHY 2YI1 3EO3 4ZHT
Enriched GO Terms of Interacting Partners?
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