GNE and GTPBP3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		GNE	GTPBP3
Description		glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	GTP binding protein 3, mitochondrial
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Mitochondrion
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding ATP Binding UDP-N-acetylglucosamine 2-epimerase Activity N-acylmannosamine Kinase Activity Metal Ion Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process N-acetylneuraminate Metabolic Process Cell Adhesion Carbohydrate Phosphorylation	TRNA Wobble Uridine Modification TRNA Methylation
Pathways		Sialic acid metabolism Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2	tRNA modification in the mitochondrion
Drugs
Diseases
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)	Mitochondrial DNA copy number ( 30704525)
Interacting Genes		66 interacting genes: ADAMTSL4 C22orf39 CFP CRMP1 CYSRT1 ECM1 EGFL7 GRN GTPBP3 HOXA1 KIAA1549 KPRP KRT31 KRT34 KRT40 KRT83 KRT85 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MGAT5B NBPF19 NID2 NOTCH2NLA PLA2G10 PRICKLE4 RIF1 SIGMAR1 SPRY1 SPRY2 SPRY3 SSC4D TRIM27 TRIM42 TRIP6 TSPAN4 VWC2 WDR83 WWOX ZBTB16	29 interacting genes: BEND7 CAPN3 CCDC32 CIC COPS5 DCAF8 DPPA4 GNE INCA1 ITGB3BP MBD3L1 MEOX2 MESD OGT PARP11 PFKL POLDIP3 PPP1R18 PRPF3 PTAFR RALY RIBC2 SERTAD3 SINHCAF TBC1D3B TBC1D3G ZFP90 ZNF69 ZNF774
Entrez ID		10020	84705
HPRD ID		04825	12255
Ensembl ID		ENSG00000159921	ENSG00000130299
Uniprot IDs		Q9Y223	B7Z563 Q969Y2
PDB IDs		2YHW 2YHY 2YI1 3EO3 4ZHT
Enriched GO Terms of Interacting Partners?
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