GUCA1A and AGR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GUCA1A	AGR2
Description		guanylate cyclase activator 1A	anterior gradient 2, protein disulphide isomerase family member
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Photoreceptor Disc Membrane Cone Photoreceptor Outer Segment	Extracellular Space Endoplasmic Reticulum
	Molecular Function	Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Guanylate Cyclase Regulator Activity	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Visual Perception Phototransduction Positive Regulation Of CGMP-mediated Signaling Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Calcium Ion	Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Negative Regulation Of Cell Death Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response
Pathways		Inactivation, recovery and regulation of the phototransduction cascade
Drugs		Myristic acid
Diseases
GWAS		Spatial processing ( 31596458)	Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		10 interacting genes: AGR2 BCKDK C1QTNF5 DDIT4L DEFB118 GSC2 GUCY2D HSPB1 KATNAL1 PRKAR1B	87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1
Entrez ID		2978	10551
HPRD ID		02648	05896
Ensembl ID		ENSG00000048545	ENSG00000106541
Uniprot IDs		B2R9P6 P43080	O95994 Q4JM46
PDB IDs			2LNS 2LNT
Enriched GO Terms of Interacting Partners?
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