AGR2 and PTTG2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		AGR2	PTTG2
Description		anterior gradient 2, protein disulphide isomerase family member	pituitary tumor-transforming 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum	Nucleus Cytoplasm
	Molecular Function	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Molecular_function SH3 Domain Binding
	Biological Process	Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Negative Regulation Of Cell Death Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response	Homologous Chromosome Segregation Chromosome Organization Negative Regulation Of Mitotic Sister Chromatid Separation
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Metabolite levels ( 23823483) Periodontal microbiota ( 22699663) Response to antidepressants (symptom remission) ( 29160301) Response to SSRI (symptom remission) ( 29160301)
Interacting Genes		87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1	13 interacting genes: AGR2 APP CSNK2B EML2 PRR20A PRR20B PRR20C PRR20D PRR20E RCOR3 RIPPLY1 SLC30A9 SUOX
Entrez ID		10551	10744
HPRD ID		05896	09176
Ensembl ID		ENSG00000106541	ENSG00000250254
Uniprot IDs		O95994 Q4JM46	Q9NZH5
PDB IDs		2LNS 2LNT
Enriched GO Terms of Interacting Partners?
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