GUCY1A2 and GSC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GUCY1A2	GSC2
Description		guanylate cyclase 1 soluble subunit alpha 2	goosecoid homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Chromatin Nucleus
	Molecular Function	Guanylate Cyclase Activity Protein Binding GTP Binding Heme Binding Protein-containing Complex Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	CGMP Biosynthetic Process Signal Transduction Positive Regulation Of Nitric Oxide Mediated Signal Transduction Intracellular Signal Transduction	Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis
Pathways		Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction
Drugs		Nitric Oxide Isosorbide mononitrate Riociguat Methylene blue Molsidomine Plecanatide
Diseases
GWAS		Anxiety disorder ( 25390645) Colorectal or endometrial cancer ( 26621817) Diastolic blood pressure ( 27841878) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Upper eyelid morphology ( 29921221) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Whole brain grey matter density ( 31530798)	Metabolite levels ( 22916037)
Interacting Genes		9 interacting genes: DLG1 DLG2 DLG3 DLG4 ERBIN GSC2 GUCY1B1 SNTA1 STUB1	61 interacting genes: ALPP ANXA5 ASPH BEST3 BNIP2 C19orf47 C1D CALM1 CALM2 CALM3 CALR CDKN2D CIAO2A COL8A1 CRCP CSNK2A1 DYRK1B EGLN3 EIF5A ETFDH FAM221B FKBP6 GALNT11 GCM2 GTF2H5 GTSF1L GUCA1A GUCY1A2 HMBOX1 ISX KDM6A KLHL38 KRT34 KRTAP5-9 LCE3E LTO1 MAD2L2 MAPK9 MARF1 MID2 MORF4L1 MRPL53 MRPS23 NME7 PACSIN2 PDE4C PRKAB2 PRODH PTER RNF4 SCAF1 SDCBP TIPIN TNPO2 TSR2 UBE2R2 VCX2 XRCC4 YPEL5 ZNF444 ZNF587
Entrez ID		2977	2928
HPRD ID		03146	03506
Ensembl ID		ENSG00000152402	ENSG00000063515
Uniprot IDs		P33402	O15499
PDB IDs
Enriched GO Terms of Interacting Partners?
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