GUCY1A2 and GUCY1B1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		GUCY1A2	GUCY1B1
Description		guanylate cyclase 1 soluble subunit alpha 2	guanylate cyclase 1 soluble subunit beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Guanylate Cyclase Complex, Soluble Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse
	Molecular Function	Guanylate Cyclase Activity Protein Binding GTP Binding Heme Binding Protein-containing Complex Binding	Adenylate Cyclase Activity Guanylate Cyclase Activity Protein Binding GTP Binding Heme Binding Signaling Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cytidylate Cyclase Activity Hsp90 Protein Binding
	Biological Process	CGMP Biosynthetic Process Signal Transduction Positive Regulation Of Nitric Oxide Mediated Signal Transduction Intracellular Signal Transduction	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Circulation CGMP-mediated Signaling Nitric Oxide-cGMP-mediated Signaling Pathway Cellular Response To Nitric Oxide Trans-synaptic Signaling By Nitric Oxide, Modulating Synaptic Transmission
Pathways		Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction	Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction
Drugs		Nitric Oxide Isosorbide mononitrate Riociguat Methylene blue Molsidomine Plecanatide
Diseases
GWAS		Anxiety disorder ( 25390645) Colorectal or endometrial cancer ( 26621817) Diastolic blood pressure ( 27841878) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Upper eyelid morphology ( 29921221) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Whole brain grey matter density ( 31530798)
Interacting Genes		9 interacting genes: DLG1 DLG2 DLG3 DLG4 ERBIN GSC2 GUCY1B1 SNTA1 STUB1	4 interacting genes: AGAP1 APP GUCY1A2 HSP90AA1
Entrez ID		2977	2983
HPRD ID		03146	00769
Ensembl ID		ENSG00000152402	ENSG00000061918
Uniprot IDs		P33402	B7Z685 B7Z6G8 B7Z9H9 D6RC99 E9PCN2 Q02153
PDB IDs			2WZ1 3UVJ 4NI2 5MNW 6JT0 6JT1 6JT2
Enriched GO Terms of Interacting Partners?
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