CYLD and PLK4

Number of citations of the paper that reports this interaction (PubMedID 31762063)
7

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CYLD	PLK4
Description		CYLD lysine 63 deubiquitinase	polo like kinase 4
Image
GO Annotations	Cellular Component	Centrosome Spindle Cytosol Cytoplasmic Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Ciliary Tip	Spindle Pole XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cleavage Furrow Deuterosome
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding Zinc Ion Binding Protein Kinase Binding Lys63-specific Deubiquitinase Activity Proline-rich Region Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Innate Immune Response Negative Regulation Of JNK Cascade Regulation Of Inflammatory Response Regulation Of Necroptotic Process Necroptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling Regulation Of Cilium Assembly Negative Regulation Of P38MAPK Cascade Protein Linear Deubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Mitotic Cell Cycle Protein Phosphorylation Centriole Replication Regulation Of Cytokinesis Positive Regulation Of Centriole Replication Cilium Assembly Trophoblast Giant Cell Differentiation De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways		NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Negative regulators of DDX58/IFIH1 signaling	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Fostamatinib
Diseases
GWAS		Adventurousness ( 30643258) Asthma (childhood onset) ( 31036433) Asthma (time to onset) ( 27130862) Body mass index ( 28892062) Crohn's disease ( 28067908 22412388) Femoral neck bone mineral density ( 29499414) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908) Leprosy ( 25642632 22019778) Lumbar spine bone mineral density ( 29499414 22504420) Serum metabolite levels ( 33031748)
Interacting Genes		24 interacting genes: AKT1 AURKB CENPV DDX58 DLG4 HDAC6 IKBKE IKBKG ITCH MAP3K7 MAPRE1 MIB2 PLK4 PTPA TBK1 TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM47 TUBA1A UBC UBE2S	22 interacting genes: ARR3 BTRC C1orf109 CHD3 CYLD DNAJB13 ELOA GAS8 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39
Entrez ID		1540	10733
HPRD ID		05427	10387
Ensembl ID		ENSG00000083799	ENSG00000142731
Uniprot IDs		A0A024R6T1 Q9NQC7	O00444
PDB IDs		1IXD 1WHL 1WHM 2VHF	2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J
Enriched GO Terms of Interacting Partners?
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