CYLD and CENPV

Number of citations of the paper that reports this interaction (PubMedID 31260673)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CYLD	CENPV
Description		CYLD lysine 63 deubiquitinase	centromere protein V
Image			No pdb structure
GO Annotations	Cellular Component	Centrosome Spindle Cytosol Cytoplasmic Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Ciliary Tip	Kinetochore Nucleus Nucleoplasm Cytosol Microtubule Cytoskeleton Midbody Nuclear Membrane Spindle Midzone
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding Zinc Ion Binding Protein Kinase Binding Lys63-specific Deubiquitinase Activity Proline-rich Region Binding	Molecular_function Protein Binding Carbon-sulfur Lyase Activity Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Innate Immune Response Negative Regulation Of JNK Cascade Regulation Of Inflammatory Response Regulation Of Necroptotic Process Necroptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling Regulation Of Cilium Assembly Negative Regulation Of P38MAPK Cascade Protein Linear Deubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Ameboidal-type Cell Migration Cell Cycle Pericentric Heterochromatin Assembly Positive Regulation Of Cytokinesis Regulation Of Chromosome Organization Centromere Complex Assembly Cell Division
Pathways		NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Asthma (childhood onset) ( 31036433) Asthma (time to onset) ( 27130862) Body mass index ( 28892062) Crohn's disease ( 28067908 22412388) Femoral neck bone mineral density ( 29499414) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908) Leprosy ( 25642632 22019778) Lumbar spine bone mineral density ( 29499414 22504420) Serum metabolite levels ( 33031748)	Adventurousness ( 30643258) Amyotrophic lateral sclerosis ( 22959728 24931836) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		24 interacting genes: AKT1 AURKB CENPV DDX58 DLG4 HDAC6 IKBKE IKBKG ITCH MAP3K7 MAPRE1 MIB2 PLK4 PTPA TBK1 TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM47 TUBA1A UBC UBE2S	1 interacting genes: CYLD
Entrez ID		1540	201161
HPRD ID		05427	12173
Ensembl ID		ENSG00000083799	ENSG00000166582
Uniprot IDs		A0A024R6T1 Q9NQC7	Q7Z7K6
PDB IDs		1IXD 1WHL 1WHM 2VHF
Enriched GO Terms of Interacting Partners?
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