GRID2 and PTPN4

Number of citations of the paper that reports this interaction (PubMedID 10748123)
23

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		GRID2	PTPN4
Description		glutamate ionotropic receptor delta type subunit 2	protein tyrosine phosphatase non-receptor type 4
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Ionotropic Glutamate Receptor Complex Dendritic Spine Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Ionotropic Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Scaffold Protein Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Ion Transmembrane Transport Cellular Protein Localization Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Excitatory Postsynaptic Potential Prepulse Inhibition Regulation Of Postsynaptic Density Assembly Positive Regulation Of Long-term Synaptic Depression Excitatory Synapse Assembly	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways			Toll Like Receptor 4 (TLR4) Cascade Interleukin-37 signaling MECP2 regulates neuronal receptors and channels
Drugs			Alendronic acid
Diseases
GWAS		Coffee consumption ( 31046077) Intelligence (MTAG) ( 29326435) Manganese levels ( 26025379) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 30456828) Obsessive-compulsive traits ( 33531474) Pancreatic beta-cell glucose sensitivity ( 32944759) Post bronchodilator FEV1/FVC ratio ( 26634245) Smoking initiation ( 33082346)	Lymphocyte counts ( 32888494)
Interacting Genes		10 interacting genes: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4	12 interacting genes: ATRX CRK EEF1A1 EEF1G GRID2 GRIN2A KAT5 LPL MAPK12 PRSS1 TK1 ZZEF1
Entrez ID		2895	5775
HPRD ID		06781	01471
Ensembl ID		ENSG00000152208	ENSG00000088179
Uniprot IDs		O43424	P29074
PDB IDs		5KC8 5KCA	2CS5 2I75 2VPH 3NFK 3NFL 5EYZ 5EZ0
Enriched GO Terms of Interacting Partners?
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