PTPN4 and ATRX

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTPN4	ATRX
Description		protein tyrosine phosphatase non-receptor type 4	ATRX chromatin remodeler
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane	Nuclear Chromosome Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Heterochromatin Nucleus Nucleoplasm Pericentric Heterochromatin Nuclear Body PML Body Chromosome, Subtelomeric Region
	Molecular Function	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding DNA Translocase Activity ATP Hydrolysis Activity Methylated Histone Binding Histone Binding Metal Ion Binding Chromo Shadow Domain Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation	Meiotic Spindle Organization DNA Repair DNA Methylation Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Spermatogenesis Positive Regulation Of Nuclear Cell Cycle DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Forebrain Development Replication Fork Processing Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Post-embryonic Forelimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Transcription By RNA Polymerase II Sertoli Cell Development Chromosome Organization Involved In Meiotic Cell Cycle Protein Localization To Chromosome, Telomeric Region Seminiferous Tubule Development Cellular Response To Hydroxyurea Regulation Of Histone H3-K9 Trimethylation Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter Positive Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric
Pathways		Toll Like Receptor 4 (TLR4) Cascade Interleukin-37 signaling MECP2 regulates neuronal receptors and channels	Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
Drugs		Alendronic acid
Diseases
GWAS		Lymphocyte counts ( 32888494)	Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		12 interacting genes: ATRX CRK EEF1A1 EEF1G GRID2 GRIN2A KAT5 LPL MAPK12 PRSS1 TK1 ZZEF1	29 interacting genes: ATN1 ATP1A3 AURKA BLM BRD9 CALM1 CCSER2 CEP126 CREBBP DAXX EZH2 H3C14 HDAC1 HDAC4 LUC7L2 MDM2 NEK1 NSD1 PTN PTPN4 RAD51 RASSF1 SUMO2 SVIL TP53 WRN ZBED1 ZMYND8 ZNF512B
Entrez ID		5775	546
HPRD ID		01471	02069
Ensembl ID		ENSG00000088179	ENSG00000085224
Uniprot IDs		P29074	A4LAA3 B4DLW1 P46100
PDB IDs		2CS5 2I75 2VPH 3NFK 3NFL 5EYZ 5EZ0	2JM1 2LBM 2LD1 3QL9 3QLA 3QLC 3QLN 4W5A 5GRQ 5Y18 5Y6O 6G0O
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?