NSMCE2 and USP28

Number of citations of the paper that reports this interaction (PubMedID 25359778)
9

Data Source:
BioGRID (enzymatic study)

		NSMCE2	USP28
Description		NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase	ubiquitin specific peptidase 28
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Body PML Body Smc5-Smc6 Complex	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Protein Binding Zinc Ion Binding SUMO Transferase Activity SUMO Ligase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Protein Sumoylation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Cellular Senescence	DNA Damage Checkpoint Signaling DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Ras Protein Signal Transduction Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		SUMOylation of DNA damage response and repair proteins	Ub-specific processing proteases
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) Behcet's disease ( 33393726) Body shape index ( 34021172) C-reactive protein levels ( 30388399) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fractures (paediatric) ( 32742401) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Pursuit maintenance gain ( 29064472) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)
Interacting Genes		5 interacting genes: ETV1 SMC5 TSNAX TXLNA USP28	40 interacting genes: ATXN3L BAP1 CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8
Entrez ID		286053	57646
HPRD ID		08131	15632
Ensembl ID		ENSG00000156831	ENSG00000048028
Uniprot IDs		A0A024R9J6 E5RFJ1 Q96MF7	B4E3L3 Q96RU2
PDB IDs		2YU4	2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK
Enriched GO Terms of Interacting Partners?
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