USP28 and UCHL5

Number of citations of the paper that reports this interaction (PubMedID 22626734)
6

Data Source:
BioGRID (enzymatic study)

		USP28	UCHL5
Description		ubiquitin specific peptidase 28	ubiquitin C-terminal hydrolase L5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex Cytosolic Proteasome Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding	RNA Binding Thiol-dependent Deubiquitinase Endopeptidase Inhibitor Activity Protein Binding Proteasome Binding
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Ras Protein Signal Transduction Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	DNA Repair DNA Recombination Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Smoothened Signaling Pathway Forebrain Morphogenesis Regulation Of Proteasomal Protein Catabolic Process
Pathways		Ub-specific processing proteases	Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)	Cannabis dependence ( 21668797)
Interacting Genes		40 interacting genes: ATXN3L BAP1 CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8	102 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1
Entrez ID		57646	51377
HPRD ID		15632	10293
Ensembl ID		ENSG00000048028	ENSG00000116750
Uniprot IDs		B4E3L3 Q96RU2	Q9Y5K5
PDB IDs		2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK	3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?
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