NSMCE2

Description		NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Body PML Body Smc5-Smc6 Complex
	Molecular Function	Protein Binding Zinc Ion Binding SUMO Transferase Activity SUMO Ligase Activity
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Protein Sumoylation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Cellular Senescence
Pathways		SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) Behcet's disease ( 33393726) Body shape index ( 34021172) C-reactive protein levels ( 30388399) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fractures (paediatric) ( 32742401) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Pursuit maintenance gain ( 29064472) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: ETV1 SMC5 TSNAX TXLNA USP28
Entrez ID		286053
HPRD ID		08131
Ensembl ID		ENSG00000156831
Uniprot IDs		A0A024R9J6 E5RFJ1 Q96MF7
PDB IDs		2YU4
Enriched GO Terms of Interacting Partners?
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