GNA15 and HRH4

Number of citations of the paper that reports this interaction (PubMedID 10973974)
80

Data Source:
HPRD (in vivo)

		GNA15	HRH4
Description		G protein subunit alpha 15	histamine receptor H4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Synapse	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Action Potential Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway	Inflammatory Response G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Biological_process Regulation Of MAPK Cascade G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Histamine receptors G alpha (i) signalling events
Drugs			Amitriptyline Clozapine Loxapine Chlorpromazine Amoxapine Doxepin Aripiprazole Pheniramine REV131 Histamine Mianserin
Diseases
GWAS		Asthma ( 31959851 34103634 32296059) Clozapine-induced myocarditis in schizophrenia ( 32066683) Glucose homeostasis traits ( 25524916) Heart failure ( 20445134) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Adult body size ( 32376654) Chronotype ( 30696823) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Lung cancer ( 34062886) Response to taxane treatment (docetaxel) ( 23006423)
Interacting Genes		19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1	6 interacting genes: ALMS1 CCL16 GNA15 GNAI1 GNAO1 SERPINB7
Entrez ID		2769	59340
HPRD ID		00760	06004
Ensembl ID		ENSG00000060558	ENSG00000134489
Uniprot IDs		P30679	B2KJ49 Q9H3N8
PDB IDs
Enriched GO Terms of Interacting Partners?
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