HiPPIP
Home
About
SZ Genes
People
Help
Advanced Search
GNA15 and CXCR2
Number of citations of the paper that reports this interaction (PubMedID
9843397
)
13
Data Source:
HPRD
(in vivo)
GNA15
CXCR2
Description
G protein subunit alpha 15
C-X-C motif chemokine receptor 2
Image
No pdb structure
GO Annotations
Cellular Component
Heterotrimeric G-protein Complex
Plasma Membrane
Synapse
Nucleoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Microtubule Cytoskeleton
Membrane
Secretory Granule Membrane
Mast Cell Granule
Mitotic Spindle
Molecular Function
G Protein-coupled Receptor Binding
GTPase Activity
GTP Binding
G-protein Beta/gamma-subunit Complex Binding
Metal Ion Binding
Interleukin-8 Receptor Activity
G Protein-coupled Receptor Activity
Protein Binding
C-C Chemokine Receptor Activity
C-X-C Chemokine Receptor Activity
C-C Chemokine Binding
Interleukin-8 Binding
Biological Process
Action Potential
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Dendritic Cell Chemotaxis
Acute Inflammatory Response To Antigenic Stimulus
Chemotaxis
Inflammatory Response
Immune Response
Cellular Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Calcium-mediated Signaling
Neutrophil Chemotaxis
Midbrain Development
Receptor Internalization
Negative Regulation Of Neutrophil Apoptotic Process
Interleukin-8-mediated Signaling Pathway
Neutrophil Activation
Positive Regulation Of Vascular Permeability
Positive Regulation Of Angiogenesis
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Metanephric Tubule Morphogenesis
Positive Regulation Of Neutrophil Chemotaxis
Pathways
PLC beta mediated events
PLC beta mediated events
G-protein activation
Acetylcholine regulates insulin secretion
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
G alpha (q) signalling events
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 1
Thromboxane signalling through TP receptor
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Thrombin signalling through proteinase activated receptors (PARs)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation
Drugs
Diseases
GWAS
Asthma (
31959851
34103634
32296059
)
Clozapine-induced myocarditis in schizophrenia (
32066683
)
Glucose homeostasis traits (
25524916
)
Heart failure (
20445134
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Neutrophil count (
32888494
)
White blood cell count (
32888494
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Granulocyte count (
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory bowel disease (
28067908
23128233
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
27863252
)
Smooth-surface caries (
23470693
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
White blood cell count (
32888494
27863252
)
Interacting Genes
19 interacting genes:
ADRB2
APP
CHRM2
CNR1
CNR2
CXCR1
CXCR2
F2R
GRK2
GRM2
GRM4
HRH4
LTB4R
OPRD1
OPRK1
OPRM1
PRKCA
RGS2
TTC1
32 interacting genes:
ADRA1A
ARRB1
ATP13A1
C4orf3
CLDN22
CXCL1
CXCL2
CXCL3
CXCL5
CXCL6
CXCL8
CXCR1
EMP1
FKBP8
GNA14
GNA15
GNAI2
GNAI3
GPRASP1
GRIA1
MYO5B
PPBP
PPP2CA
RAB11FIP2
RGS12
SLC18A2
SLC39A2
SMCO4
ST13
TMEM147
TMEM80
TRARG1
Entrez ID
2769
3579
HPRD ID
00760
00907
Ensembl ID
ENSG00000060558
ENSG00000180871
Uniprot IDs
P30679
P25025
Q53PC4
PDB IDs
4Q3H
5TYT
6KVA
6KVF
6LFM
6LFO
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?