HRH4 and SERPINB7

		HRH4	SERPINB7
Description		histamine receptor H4	serpin family B member 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse	Extracellular Space Cytoplasm
	Molecular Function	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Biological_process Regulation Of MAPK Cascade G Protein-coupled Serotonin Receptor Signaling Pathway	Negative Regulation Of Endopeptidase Activity Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Platelet-derived Growth Factor Production
Pathways		Histamine receptors G alpha (i) signalling events
Drugs		Amitriptyline Clozapine Loxapine Chlorpromazine Amoxapine Doxepin Aripiprazole Pheniramine REV131 Histamine Mianserin
Diseases
GWAS		Adult body size ( 32376654) Chronotype ( 30696823) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Lung cancer ( 34062886) Response to taxane treatment (docetaxel) ( 23006423)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31361310 30929738 34103634 32296059 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Food allergy ( 29051540) Hen's egg allergy ( 29051540) Systolic blood pressure ( 29208002)
Interacting Genes		6 interacting genes: ALMS1 CCL16 GNA15 GNAI1 GNAO1 SERPINB7	10 interacting genes: FBXO22 HRH4 OGDH PHLPP1 PIGN RELCH RNF152 SLC5A2 TAX1BP1 ZCCHC2
Entrez ID		59340	8710
HPRD ID		06004	04524
Ensembl ID		ENSG00000134489	ENSG00000166396
Uniprot IDs		B2KJ49 Q9H3N8	A8K3Q8 O75635
PDB IDs
Enriched GO Terms of Interacting Partners?
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