GLRX and TRIM62

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GLRX	TRIM62
Description		glutaredoxin	tripartite motif containing 62
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Glutathione-disulfide Reductase (NADPH) Activity Protein Binding Glutathione Disulfide Oxidoreductase Activity Protein N-terminus Binding Glutathione Oxidoreductase Activity	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nucleobase-containing Small Molecule Interconversion Positive Regulation Of Membrane Potential Protein Deglutathionylation Cellular Oxidant Detoxification Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Negative Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein K27-linked Ubiquitination Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Viral Release From Host Cell Positive Regulation Of Antifungal Innate Immune Response
Pathways		Interconversion of nucleotide di- and triphosphates	Interferon gamma signaling
Drugs		Glutathione
Diseases
GWAS		hemolysis of donated blood (oxidative) ( 34014839) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Metabolite levels ( 23823483) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Gut microbiota (beta diversity) ( 27723756)
Interacting Genes		8 interacting genes: AQP5 CASP3 GOT2 MAP3K5 MMP23B NFIC PTPN1 TRIM62	19 interacting genes: CARD9 EAF1 EPN2 EXOSC5 FAIM GLRX PPP1R18 SKIL SMAD2 SP7 TBC1D7 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2L6 UBXN7 UTP25
Entrez ID		2745	55223
HPRD ID		02707	07697
Ensembl ID		ENSG00000173221	ENSG00000116525
Uniprot IDs		A0A024RAM2 P35754	Q9BVG3
PDB IDs		1B4Q 1JHB 4RQR
Enriched GO Terms of Interacting Partners?
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