GLI2 and SUFU

Number of citations of the paper that reports this interaction (PubMedID 10564661)
60

Data Source:
HPRD (in vitro)

		GLI2	SUFU
Description		GLI family zinc finger 2	SUFU negative regulator of hedgehog signaling
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Cilium Axoneme Membrane Nuclear Speck Motile Cilium Ciliary Tip Ciliary Base	Nucleus Nucleoplasm Cytoplasm Cytosol Ciliary Tip Ciliary Base
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development In Utero Embryonic Development Kidney Development Chondrocyte Differentiation Osteoblast Development Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Pattern Specification Process Axon Guidance Ventral Midline Development Hindgut Morphogenesis Heart Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Floor Plate Formation Spinal Cord Dorsal/ventral Patterning Ventral Spinal Cord Development Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Spinal Cord Ventral Commissure Morphogenesis Pituitary Gland Development Lung Development Mammary Gland Development Hindbrain Development Hair Follicle Morphogenesis Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of T Cell Differentiation In Thymus Tube Development Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Development Developmental Growth Neuron Development Branching Morphogenesis Of An Epithelial Tube Notochord Regression Prostatic Bud Formation Mammary Gland Duct Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cellular Response To Organic Cyclic Compound Cochlea Morphogenesis Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Neural Tube Closure Heart Looping Ventricular Septum Development Regulation Of Transcription, DNA-templated Proteolysis Signal Transduction Multicellular Organism Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Aorta Development Negative Regulation Of Protein Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Skin Development Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Coronary Vasculature Development Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Degradation of GLI2 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription RUNX2 regulates chondrocyte maturation	Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state
Drugs
Diseases
GWAS		Acne (severe) ( 30542056) Age-related macular degeneration ( 23326517) Breast size ( 22747683) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Erectile dysfunction and prostate cancer treatment ( 20932654) Estimated glomerular filtration rate ( 31015462) Estimated glomerular filtration rate in coronary artery disease and impaired kidney function ( 30809046) Glomerular filtration rate (creatinine) ( 26831199) Height ( 28552196 25429064 31562340) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels ( 30993211) Type 2 diabetes ( 30054458 30297969) Waist circumference adjusted for body mass index ( 34021172) Weight ( 34074324)	Adult body size ( 32376654) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergy ( 27182965) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Creatinine levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Nickel levels ( 26025379) Optic disc size ( 31809533) Platelet count ( 32888494) Prostate cancer ( 23535732) Refractive error ( 32231278) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White blood cell count ( 29403010)
Interacting Genes		13 interacting genes: AR BTRC CREB1 FBXW11 HSPD1 OTUB2 SKI SPOP STK36 SUFU TAF9 ZIC1 ZIC2	51 interacting genes: ABI3 AKR1C1 BFSP2 BTRC CRTC2 CRX DISC1 EDA2R FBXL17 FXR1 GLI1 GLI2 GLI3 GLIS3 HDX HMGA1 HNRNPA1 ITCH KRT27 KRT75 L3MBTL3 LAMTOR3 LCA5 LGALS3 LZTS1 MAGEL2 MEOX2 MID1IP1 NCOA3 PEX26 PIAS1 QPRT RBPJ RCN3 RNF19A SAP18 SETDB1 SH3RF1 SLC41A3 STK36 STX19 TLE5 ZIC1 ZNF114 ZNF219 ZNF263 ZNF330 ZNF446 ZNF763 ZNF764 ZSCAN18
Entrez ID		2736	51684
HPRD ID		01312	06124
Ensembl ID		ENSG00000074047	ENSG00000107882
Uniprot IDs		P10070 Q1PSW9 Q59FV5	A0A223LX15 Q9UMX1
PDB IDs			1M1L 4BL8 4BL9 4BLA 4BLB 4BLD 4KM8 4KM9 4KMD 4KMH
Enriched GO Terms of Interacting Partners?
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