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GLI2 and STK36
Number of citations of the paper that reports this interaction (PubMedID
10806483
)
38
Data Source:
HPRD
(in vivo)
GLI2
STK36
Description
GLI family zinc finger 2
serine/threonine kinase 36
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Cilium
Axoneme
Membrane
Nuclear Speck
Motile Cilium
Ciliary Tip
Ciliary Base
Extracellular Region
Nucleus
Cytoplasm
Cytosol
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
In Utero Embryonic Development
Kidney Development
Chondrocyte Differentiation
Osteoblast Development
Regulation Of Transcription By RNA Polymerase II
Smoothened Signaling Pathway
Pattern Specification Process
Axon Guidance
Ventral Midline Development
Hindgut Morphogenesis
Heart Development
Anterior/posterior Pattern Specification
Proximal/distal Pattern Formation
Floor Plate Formation
Spinal Cord Dorsal/ventral Patterning
Ventral Spinal Cord Development
Cerebellar Cortex Morphogenesis
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification
Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification
Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation
Spinal Cord Ventral Commissure Morphogenesis
Pituitary Gland Development
Lung Development
Mammary Gland Development
Hindbrain Development
Hair Follicle Morphogenesis
Negative Regulation Of Chondrocyte Differentiation
Positive Regulation Of T Cell Differentiation In Thymus
Tube Development
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Differentiation
Positive Regulation Of DNA Replication
Negative Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Digestive Tract Development
Developmental Growth
Neuron Development
Branching Morphogenesis Of An Epithelial Tube
Notochord Regression
Prostatic Bud Formation
Mammary Gland Duct Morphogenesis
Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Cellular Response To Organic Cyclic Compound
Cochlea Morphogenesis
Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Epithelial Cilium Movement Involved In Extracellular Fluid Movement
Protein Phosphorylation
Smoothened Signaling Pathway
Positive Regulation Of Hh Target Transcription Factor Activity
Brain Development
Post-embryonic Development
Positive Regulation Of Smoothened Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Cilium Assembly
Pathways
Degradation of GLI2 by the proteasome
Hedgehog 'off' state
Hedgehog 'on' state
GLI proteins bind promoters of Hh responsive genes to promote transcription
RUNX2 regulates chondrocyte maturation
Drugs
Fostamatinib
Diseases
GWAS
Acne (severe) (
30542056
)
Age-related macular degeneration (
23326517
)
Breast size (
22747683
)
Diastolic blood pressure (
30224653
)
Diisocyanate-induced asthma (
25918132
)
Erectile dysfunction and prostate cancer treatment (
20932654
)
Estimated glomerular filtration rate (
31015462
)
Estimated glomerular filtration rate in coronary artery disease and impaired kidney function (
30809046
)
Glomerular filtration rate (creatinine) (
26831199
)
Height (
28552196
25429064
31562340
)
Serum alkaline phosphatase levels (
33547301
)
Serum uric acid levels (
30993211
)
Type 2 diabetes (
30054458
30297969
)
Waist circumference adjusted for body mass index (
34021172
)
Weight (
34074324
)
Amyotrophic lateral sclerosis (
22959728
)
Body mass index and triglycerides (pairwise) (
33619380
)
Hematocrit (
27863252
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Male-pattern baldness (
28196072
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Interacting Genes
13 interacting genes:
AR
BTRC
CREB1
FBXW11
HSPD1
OTUB2
SKI
SPOP
STK36
SUFU
TAF9
ZIC1
ZIC2
10 interacting genes:
CDK5RAP2
CDK9
CLNK
FRMPD4
GLI1
GLI2
GLI3
MAST2
MID1
SUFU
Entrez ID
2736
27148
HPRD ID
01312
09631
Ensembl ID
ENSG00000074047
ENSG00000163482
Uniprot IDs
P10070
Q1PSW9
Q59FV5
A0A140VJW1
Q9NRP7
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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