DESI1 and UHRF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DESI1	UHRF2
Description		desumoylating isopeptidase 1	ubiquitin like with PHD and ring finger domains 2
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GO Annotations	Cellular Component	Nucleus Cytosol Protein-containing Complex	Heterochromatin Nucleus Nucleoplasm Pericentric Heterochromatin
	Molecular Function	Protein Binding Identical Protein Binding Importin-alpha Family Protein Binding SUMO-specific Isopeptidase Activity	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding SUMO Transferase Activity Histone Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Export From Nucleus Protein Desumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Removal	Cell Cycle Maintenance Of DNA Methylation Protein Ubiquitination Protein Sumoylation Cell Differentiation Regulation Of Cell Cycle Protein Autoubiquitination
Pathways			SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Periodontal microbiota ( 22699663)
Interacting Genes		35 interacting genes: ABI3 AGR3 CCDC158 CDIP1 CDSN CENPM CTAG1A CTAG1B CTAG2 DAZAP2 ERP29 EVI2B FGF7 GOLM1 KLRF1 MEOX2 NME3 NT5C3A PRR5 RBX1 RNF4 RPS27A SHISA4 SHISA5 SLC25A17 SMIM21 TAS2R41 UBA52 UBB UBC UBQLN1 UBQLNL UHRF2 XPO1 ZBTB46	40 interacting genes: ATXN1 BAX BCAR1 BCL2L1 CCND1 CD27 CDK1 CDK2 CDK4 CDK6 CTNNB1 DESI1 FANCD2 FYN H3C1 HMGB1 HMGB2 JAK3 LCK LYN MCL1 PCNP PTPRC RAD51 RBCK1 RUNX1 SKP1 SMAD4 TP53 TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2W UHRF1 YY1 ZNF410 ZNF618
Entrez ID		27351	115426
HPRD ID		18590	18257
Ensembl ID		ENSG00000100418	ENSG00000147854
Uniprot IDs		Q6ICB0	Q96PU4
PDB IDs		3EBQ	1WY8 1Z6U 2E6S 3OLN 4PW5 4PW6 4PW7 4TVR 5YCO
Enriched GO Terms of Interacting Partners?
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