RPS6KA6 and MED24

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		RPS6KA6	MED24
Description		ribosomal protein S6 kinase A6	mediator complex subunit 24
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding Protein-containing Complex Binding Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	Protein Ubiquitination Histone Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Pathways		Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs		Fostamatinib
Diseases
GWAS			Asthma ( 31619474) Bipolar disorder ( 31043756) Eosinophil counts ( 32888494) Estimated glomerular filtration rate ( 31152163) Mitochondrial DNA copy number ( 30704525) Neutrophil count ( 25096241 29403010) Neutrophil percentage of white cells ( 32888494) Pancreatic ductal adenocarcinoma ( 30541042) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) White blood cell count ( 22037903 32888494 20139978 21738480 28158719)
Interacting Genes		28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	14 interacting genes: APP AR CTDP1 ESR1 ESR2 GSK3B HNF4A MED9 PPARA PPARG RPS6KA6 RXRA SREBF1 TNFSF11
Entrez ID		27330	9862
HPRD ID		02250	06107
Ensembl ID		ENSG00000072133	ENSG00000008838
Uniprot IDs		Q9UK32	F5GY88 O75448
PDB IDs		6G76 6G77 6G78
Enriched GO Terms of Interacting Partners?
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