RPS6KA6 and UFM1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		RPS6KA6	UFM1
Description		ribosomal protein S6 kinase A6	ubiquitin fold modifier 1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol	Nucleus Cytoplasm Endoplasmic Reticulum
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	Brain Development Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Reticulophagy Protein Ufmylation Protein K69-linked Ufmylation
Pathways		Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation
Drugs		Fostamatinib
Diseases
GWAS			Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Low vWF levels ( 26486471) Schizophrenia ( 33169155 30285260)
Interacting Genes		28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	16 interacting genes: ARHGDIA ARHGDIB DIABLO GSK3B INCA1 KCTD21 RPS6KA6 TSC22D2 UBA5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2W
Entrez ID		27330	51569
HPRD ID		02250	15644
Ensembl ID		ENSG00000072133	ENSG00000120686
Uniprot IDs		Q9UK32	P61960
PDB IDs		6G76 6G77 6G78	1WXS 5HKH 5IA7 5IA8 5IAA 5L95 6H77
Enriched GO Terms of Interacting Partners?
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