RPS6KA6 and FBN3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		RPS6KA6	FBN3
Description		ribosomal protein S6 kinase A6	fibrillin 3
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol	Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Extracellular Matrix Structural Constituent Calcium Ion Binding
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	Anatomical Structure Morphogenesis
Pathways		Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Fostamatinib	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS			Attention deficit hyperactivity disorder ( 30563984) Blood protein levels ( 28240269) Macular telangiectasia type 2 ( 33654266) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Pre-treatment viral load in HIV-1 infection ( 31219150) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352)
Interacting Genes		28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	13 interacting genes: ANXA7 BID C11orf58 CDKN1A DAZAP2 GADD45A GSK3B NUDT21 PIK3R3 RPN2 RPS6KA6 TK1 TSC22D1
Entrez ID		27330	84467
HPRD ID		02250	10538
Ensembl ID		ENSG00000072133	ENSG00000142449
Uniprot IDs		Q9UK32	A0A494C0D8 A8KAY2 Q75N90
PDB IDs		6G76 6G77 6G78
Enriched GO Terms of Interacting Partners?
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