SMPDL3B and ARID1A

		SMPDL3B	ARID1A
Description		sphingomyelin phosphodiesterase acid like 3B	AT-rich interaction domain 1A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Anchored Component Of Membrane Extracellular Exosome	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Brahma Complex NpBAF Complex NBAF Complex
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds	DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Nucleosome Binding
	Biological Process	Sphingomyelin Catabolic Process Inflammatory Response Biological_process Negative Regulation Of Toll-like Receptor Signaling Pathway Innate Immune Response Membrane Lipid Catabolic Process Negative Regulation Of Inflammatory Response	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Intracellular Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Nucleosome Mobilization Glucocorticoid Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Chromatin-mediated Maintenance Of Transcription
Pathways			RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549 28869591) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver volume ( 34128465) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 33339817) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) White matter hyperintensities in ischemic stroke ( 26674333)
Interacting Genes		2 interacting genes: ARID1A OGT	24 interacting genes: CDC123 EDEM1 ESR1 EWSR1 FUS GATA1 GMEB1 HIC1 ITCH KLF1 MLLT1 NCOA1 NEDD4 PGR RARA RARB RARG SMARCA4 SMPDL3B TAF12 TAF15 THEMIS2 TP53 VPS41
Entrez ID		27293	8289
HPRD ID		15405	04319
Ensembl ID		ENSG00000130768	ENSG00000117713
Uniprot IDs		B4DEC6 B4DW34 Q92485	O14497
PDB IDs			1RYU 6LTH 6LTJ
Enriched GO Terms of Interacting Partners?
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