DISC1 and PDE4B

  • Number of citations of the paper that reports this interaction (PubMedID 17043677)
  • 193
  • Data Source:
  • BioGRID (two hybrid)

DISC1

PDE4B

Description DISC1 scaffold protein phosphodiesterase 4B
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alzheimer's disease ( 19118814)
  • Amyotrophic lateral sclerosis ( 19451621)
  • Amyotrophic lateral sclerosis (sporadic) ( 24529757)
  • Arterial stiffness index ( 31235810)
  • Bell's palsy ( 33602968)
  • Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451)
  • Metabolite levels ( 23823483)
  • Neuranatomic and neurocognitive phenotypes ( 21483430)
  • Pelvic organ prolapse (moderate/severe) ( 26545240)
  • Response to antidepressants (symptom improvement) ( 29160301)
  • Response to antineoplastic agents ( 21659360)
  • Response to statin therapy ( 20339536)
  • Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592)
  • Waist circumference ( 28552196)
  • Acute lymphoblastic leukemia (childhood) ( 22076464 23007406)
  • Adult body size ( 32376654)
  • Age at first birth ( 34211149)
  • Age at first sexual intercourse ( 34211149)
  • Age at voice drop ( 27182965)
  • Alanine aminotransferase levels ( 33547301)
  • Alcohol consumption ( 31358974)
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Anxiety and stress-related disorders ( 31116379)
  • Anxiety and stress-related disorders (excluding adjustment disorder) ( 31116379)
  • Anxiety and stress-related disorders (excluding co-morbid schizophrenia) ( 31116379)
  • Anxiety and stress-related disorders (including obsessive-compulsive disorder) ( 31116379)
  • Anxiety and stress-related disorders (psychiatric co-morbidity covariate model) ( 31116379)
  • Anxiety and stress-related disorders (psychiatric co-morbidity weighting design) ( 31116379)
  • Anxiety disorders ( 31116379)
  • Aspartate aminotransferase levels ( 33547301)
  • Birth weight ( 31043758)
  • Body size at age 10 ( 32376654)
  • C-reactive protein levels ( 33339817)
  • Chronotype ( 30696823)
  • Echocardiographic traits ( 17903301)
  • Economic and political preferences (feminism/equality) ( 22566634)
  • Fibrinogen levels ( 28107422)
  • Gastroesophageal reflux disease ( 31527586)
  • Low tan response ( 29739929)
  • Multiple sclerosis ( 31604244)
  • Phenylephrine infusion rate during anesthesia ( 31455332)
  • Problematic alcohol use ( 32451486)
  • QT interval ( 29213071)
  • Risk-taking tendency (4-domain principal component model) ( 30643258)
  • Rosacea symptom severity ( 29771307)
  • Schizophrenia ( 30285260)
  • Sleep duration (short sleep) ( 30846698)
  • Smoking initiation ( 30617275 33082346)
  • Smoking initiation (ever regular vs never regular) ( 30679032)
  • Smoking status (ever vs never smokers) ( 30643258)
  • Staphylococcus aureus infection ( 24847357)
  • Stress-related disorders ( 31116379)
Interacting Genes 194 interacting genes: ABI2 ACTG1 ACTN2 ADO AGTPBP1 AIMP2 AKAP6 ALDH3A2 AMOT AP1M1 ARIH2 ARMC7 ATF4 ATF5 ATF7IP BAG2 BFSP2 BICD1 BORCS6 BRD1 C1orf109 C2CD6 C8orf33 CARD9 CCDC102B CCDC13 CCDC136 CCDC141 CCDC197 CCDC24 CCDC57 CCDC88A CCDC92 CCHCR1 CDC23 CDC37 CDC5L CDK5RAP3 CDKL3 CEP126 CEP57 CEP57L1 CEP63 CFAP206 CIT CLU CNST COL4A1 CTNNA3 CWF19L2 DCTN1 DCTN2 DDX6 DEGS1 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EGLN1 EIF3H EIF4A3 EMSY EXOC1 EXOC4 EXOC7 EXTL1 FBXO34 FBXO41 FBXW7 FEZ1 FLACC1 FRYL GABARAPL1 GAS2L2 GAS8 GCC1 GEM GNB1 GNG13 GNPTAB GPANK1 GPRASP2 GRIPAP1 GSK3B HERC2P2 HNRNPC IFT20 IFT74 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIF3A KIF3C KIF9 KIFAP3 KIFC3 LENG1 MACF1 MAP1A MEMO1 MLLT10 MNS1 MORF4L2 MPPED1 MVP MYH7 MYT1L NCK2 NDE1 NDEL1 NECAB1 NEFM NME7 NSRP1 NUP160 OLFM1 PCNT PCNX4 PDE4B PGK1 PHF1 PIBF1 PIK3R3 PKN1 POLR3C PPFIA3 PPM1E PPP4R1 PPP5C PSPC1 QARS1 RABGAP1 RAD21 RANBP9 RASSF7 RBM41 RBSN RECK RNF40 ROGDI RTRAF SH3BP5 SMARCD1 SMARCE1 SMC2 SMC3 SMC5 SMYD1 SNX6 SPARCL1 SPATC1L SPTBN4 SRGAP2 SRGAP3 STX11 STX18 SUFU SYBU SYNE1 TCAF1 TCEANC TFIP11 TIAM2 TNKS TP53BP2 TRAF3IP1 TRAF4 TRIM29 TRIM68 TRIO TSGA10 TSPOAP1 TSR2 TTC23 TUBB TUBB2A UBASH3A UBASH3B USP2 UTRN XPNPEP1 YWHAE YWHAG YWHAQ YWHAZ ZNF124 ZNF197 ZNF365 ZNF76 6 interacting genes: DISC1 MAGEA11 PRKACA RCBTB2 SLIT2 SMURF2
Entrez ID 27185 5142
HPRD ID 05553 02528
Ensembl ID ENSG00000162946 ENSG00000184588
Uniprot IDs C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5 Q07343 Q59GM8 Q68CX5 X5DNX5 X5DR82
PDB IDs 5V4B 1F0J 1JP1 1JP2 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3FRG 3G45 3GWT 3HC8 3HDZ 3HMV 3KKT 3LY2 3O0J 3O56 3O57 3W5E 3WD9 4KP6 4MYQ 4NW7 4WZI 4X0F 5K6J 5LAQ 5OHJ 6BOJ
Enriched GO Terms of Interacting Partners?
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