DISC1 and GSK3B

  • Number of citations of the paper that reports this interaction (PubMedID 28727686)
  • 10
  • Data Source:
  • BioGRID (enzymatic study)

DISC1

GSK3B

Description DISC1 scaffold protein glycogen synthase kinase 3 beta
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alzheimer's disease ( 19118814)
  • Amyotrophic lateral sclerosis ( 19451621)
  • Amyotrophic lateral sclerosis (sporadic) ( 24529757)
  • Arterial stiffness index ( 31235810)
  • Bell's palsy ( 33602968)
  • Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451)
  • Metabolite levels ( 23823483)
  • Neuranatomic and neurocognitive phenotypes ( 21483430)
  • Pelvic organ prolapse (moderate/severe) ( 26545240)
  • Response to antidepressants (symptom improvement) ( 29160301)
  • Response to antineoplastic agents ( 21659360)
  • Response to statin therapy ( 20339536)
  • Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592)
  • Waist circumference ( 28552196)
  • HDL cholesterol ( 24097068)
  • HDL cholesterol levels ( 28334899)
  • Hippocampal volume in Alzheimer's disease dementia ( 29274321)
  • Liver enzyme levels (alkaline phosphatase) ( 33972514)
  • Low density lipoprotein cholesterol levels ( 32154731)
  • Neutrophil count ( 32888494)
  • Platelet distribution width ( 32888494)
  • Serum alkaline phosphatase levels ( 33547301)
Interacting Genes 194 interacting genes: ABI2 ACTG1 ACTN2 ADO AGTPBP1 AIMP2 AKAP6 ALDH3A2 AMOT AP1M1 ARIH2 ARMC7 ATF4 ATF5 ATF7IP BAG2 BFSP2 BICD1 BORCS6 BRD1 C1orf109 C2CD6 C8orf33 CARD9 CCDC102B CCDC13 CCDC136 CCDC141 CCDC197 CCDC24 CCDC57 CCDC88A CCDC92 CCHCR1 CDC23 CDC37 CDC5L CDK5RAP3 CDKL3 CEP126 CEP57 CEP57L1 CEP63 CFAP206 CIT CLU CNST COL4A1 CTNNA3 CWF19L2 DCTN1 DCTN2 DDX6 DEGS1 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EGLN1 EIF3H EIF4A3 EMSY EXOC1 EXOC4 EXOC7 EXTL1 FBXO34 FBXO41 FBXW7 FEZ1 FLACC1 FRYL GABARAPL1 GAS2L2 GAS8 GCC1 GEM GNB1 GNG13 GNPTAB GPANK1 GPRASP2 GRIPAP1 GSK3B HERC2P2 HNRNPC IFT20 IFT74 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIF3A KIF3C KIF9 KIFAP3 KIFC3 LENG1 MACF1 MAP1A MEMO1 MLLT10 MNS1 MORF4L2 MPPED1 MVP MYH7 MYT1L NCK2 NDE1 NDEL1 NECAB1 NEFM NME7 NSRP1 NUP160 OLFM1 PCNT PCNX4 PDE4B PGK1 PHF1 PIBF1 PIK3R3 PKN1 POLR3C PPFIA3 PPM1E PPP4R1 PPP5C PSPC1 QARS1 RABGAP1 RAD21 RANBP9 RASSF7 RBM41 RBSN RECK RNF40 ROGDI RTRAF SH3BP5 SMARCD1 SMARCE1 SMC2 SMC3 SMC5 SMYD1 SNX6 SPARCL1 SPATC1L SPTBN4 SRGAP2 SRGAP3 STX11 STX18 SUFU SYBU SYNE1 TCAF1 TCEANC TFIP11 TIAM2 TNKS TP53BP2 TRAF3IP1 TRAF4 TRIM29 TRIM68 TRIO TSGA10 TSPOAP1 TSR2 TTC23 TUBB TUBB2A UBASH3A UBASH3B USP2 UTRN XPNPEP1 YWHAE YWHAG YWHAQ YWHAZ ZNF124 ZNF197 ZNF365 ZNF76 244 interacting genes: ACLY ACSBG1 ACTL6B ADAP1 ADIRF AKAP11 AKT1 AKT2 AKT3 APC APP AR ARRB1 ASRGL1 ATP5IF1 ATXN3 AURKA AXIN1 AXIN2 BAG6 BCCIP BCL2A1 BCL2L1 BCL3 BEX1 BHLHE41 BICD1 BICD2 BRIX1 BTRC BZW2 C10orf90 C11orf98 CABYR CAMSAP3 CCND1 CCNE1 CDH1 CDK5 CDX2 CEBPA CEBPD CEBPZ CENPB CHD3 CIITA CLEC3B CMTM2 CREB1 CREB3L3 CREM CSAD CSNK2B CST6 CTNNB1 CTNND1 DBI DCP1B DCTN1 DCTN2 DCTN3 DDIT4 DEAF1 DEFA1 DELEC1 DHX34 DISC1 DNAJC13 DNM1L DNMT1 DNMT3L DPYSL2 DRD3 DUSP9 DYNC1I1 E2F1 EEF1G EFTUD2 EIF2B5 EIF4EBP1 ENTPD6 ERG28 EYA1 FAM193B FAM83D FBN3 FBXL21P FBXO7 FBXW11 FEN1 FIBP FKBP14 FOXO1 FRAT1 FRAT2 FZD5 GBP2 GFI1 GIPC1 GJB5 GNB2 GOLM2 GPR39 GYS1 HDAC4 HNRNPD HNRNPM HSP90AA1 HSP90AB1 HSPA4 IGHM IGSF21 IKBKG ILK IQCG IRF1 JUN KDM1A KHSRP KIAA1191 KIF5B KLF2 KLF5 LMO4 LPCAT1 LRP6 LUC7L2 LYAR MAP1B MAP3K1 MAP3K4 MAP4 MAPK1 MAPT MARK2 MASP1 MCL1 MDM2 MED24 MICAL1 MID1IP1 MITF MPP1 MTF2 MTOR MUC1 MYC MYL6 MYOCD NAT9 NBR1 NCOA3 NDRG1 NFE2L1 NFE2L2 NFE2L3 NFKB1 NIN NOTCH1 NOTCH2 NRBP1 NSFL1C OGA OGT PDE4D PFKFB4 PHLPP1 PIAS1 PIM2 PMAIP1 PPARGC1A PPP1R2 PRKACA PRKCA PRKCB PRKCZ PRKDC PRKRIP1 PSEN1 PSMD8 PTK2 PTN PTPN1 PXN QARS1 RAI1 RBPJ RCAN1 RELB RICTOR RPL36AL RPLP1 RPS15 RPS2 RPS6KA1 RSU1 RXRA SAP30BP SGK1 SGK3 SLA SMAD3 SMG7 SNAI1 SNCA SNCAIP SOX10 SPI1 SPTBN4 SREBF1 STAT2 SYNE4 TAFAZZIN TCAP TEKT5 TLE1 TMEM132A TMEM44 TNFAIP3 TONSL TP53 TPPP TRAF6 TSC2 TUBA1A UBE2D1 UBR1 UBR5 UBXN6 UFM1 UPF3A VIM VPS51 WSB1 XIAP XPNPEP1 YBX1 YBX3 YWHAZ ZFPM1 ZHX1 ZNF135 ZNF227 ZNF746
Entrez ID 27185 2932
HPRD ID 05553 05418
Ensembl ID ENSG00000162946 ENSG00000082701
Uniprot IDs C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5 P49841 Q6FI27
PDB IDs 5V4B 1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2O5K 2OW3 2UW9 2X39 2XH5 3CQU 3CQW 3DU8 3E87 3E88 3E8D 3F7Z 3F88 3GB2 3I4B 3L1S 3M1S 3MV5 3OW4 3PUP 3Q3B 3QKK 3SAY 3SD0 3ZDI 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH 4AFJ 4B7T 4DIT 4EKK 4IQ6 4J1R 4J71 4NM0 4NM3 4NM5 4NM7 4PTC 4PTE 4PTG 5F94 5F95 5HLN 5HLP 5K5N 5KPK 5KPL 5KPM 5OY4 5T31 6B8J 6BUU 6GJO 6GN1 6H0U 6HK3 6HK4 6HK7 6NPZ 6TCU 6V6L 6Y9R 6Y9S 7B6F
Enriched GO Terms of Interacting Partners?
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