GLS2 and RGS3

Number of citations of the paper that reports this interaction (PubMedID 16637659)
29

Data Source:
HPRD (in vitro)

		GLS2	RGS3
Description		glutaminase 2	regulator of G protein signaling 3
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Cytosol Plasma Membrane
	Molecular Function	Glutaminase Activity Protein Binding	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Cellular Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Catabolic Process Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Catalytic Activity
Pathways		Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism	G alpha (q) signalling events G alpha (i) signalling events
Drugs		Glutamic acid
Diseases
GWAS		Adverse response to drug ( 30420678) Amino acid levels ( 26068415) Apolipoprotein A1 levels ( 33730874) Axial length ( 24144296) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Glycine levels ( 30837465) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271)	Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR HIP1 OS9 PAG1 PATJ PDE2A RALA RGS3 SLC26A4-AS1 SNTA1 TAX1BP3 XAF1	25 interacting genes: ACD APP CDK6 CNKSR2 CYSRT1 DEPDC1B EFNB1 EFNB2 ESR1 GLS2 GNA11 GNAI3 GORASP2 GRIN2A HES4 HIPK3 MAPK12 PAX6 PLSCR1 PRKN SCN5A YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		27165	5998
HPRD ID		05901	03720
Ensembl ID		ENSG00000135423	ENSG00000138835
Uniprot IDs		A0A087X004 Q9UI32	A0A024R831 A0A024R833 A0A024R841 B3KVT7 B3KWG8 H7BXY1 P49796 Q53GP3
PDB IDs		4BQM 5U0K	2F5Y 2OJ4 3FBK
Enriched GO Terms of Interacting Partners?
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