GLS2 and XAF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GLS2	XAF1
Description		glutaminase 2	XIAP associated factor 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleoplasm Mitochondrion Cytosol
	Molecular Function	Glutaminase Activity Protein Binding	Protein Binding Zinc Ion Binding
	Biological Process	Cellular Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Catabolic Process Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process	Apoptotic Process Response To Interferon-beta
Pathways		Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism	Interferon alpha/beta signaling
Drugs		Glutamic acid
Diseases
GWAS		Adverse response to drug ( 30420678) Amino acid levels ( 26068415) Apolipoprotein A1 levels ( 33730874) Axial length ( 24144296) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Glycine levels ( 30837465) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		17 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR HIP1 OS9 PAG1 PATJ PDE2A RALA RGS3 SLC26A4-AS1 SNTA1 TAX1BP3 XAF1	18 interacting genes: AKT1 APP BIRC7 CREBBP GLS2 LRSAM1 RFC5 RNF114 RNF166 SEPHS1 TP53 TRIM21 TRIM50 TRIM54 TRIML2 UBXN2B VCP XIAP
Entrez ID		27165	54739
HPRD ID		05901	06978
Ensembl ID		ENSG00000135423	ENSG00000132530
Uniprot IDs		A0A087X004 Q9UI32	Q6GPH4
PDB IDs		4BQM 5U0K	2LXW
Enriched GO Terms of Interacting Partners?
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