GLS2 and HIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GLS2	HIP1
Description		glutaminase 2	huntingtin interacting protein 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Intracellular Membrane-bounded Organelle Presynapse Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Glutaminase Activity Protein Binding	Epidermal Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Glutamate Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Cellular Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Catabolic Process Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process	Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Protein Kinase B Signaling Clathrin-dependent Endocytosis Apoptotic Signaling Pathway Neurotransmitter Receptor Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism	Clathrin-mediated endocytosis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs		Glutamic acid
Diseases
GWAS		Adverse response to drug ( 30420678) Amino acid levels ( 26068415) Apolipoprotein A1 levels ( 33730874) Axial length ( 24144296) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Glycine levels ( 30837465) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271)	Age-related nuclear cataracts ( 24951543) Alcoholism (12-month weekly alcohol consumption) ( 21529783) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26961502 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Fasting insulin ( 33402679) Interleukin-6 levels ( 22205395) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)
Interacting Genes		17 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR HIP1 OS9 PAG1 PATJ PDE2A RALA RGS3 SLC26A4-AS1 SNTA1 TAX1BP3 XAF1	37 interacting genes: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CFAP53 CLTA CLTB CLTC CYRIB DAZAP2 DVL2 EHHADH EIF6 FAM168A FBXO25 GLS2 HIP1R HTT IFT57 ITSN1 LITAF LNX1 MAP3K1 MAPK6 NECAP1 PFDN1 RAD23B REL RPRM RPS10 SMURF1 SYT17 TCEA2 TCEANC TFAP2A
Entrez ID		27165	3092
HPRD ID		05901	03461
Ensembl ID		ENSG00000135423	ENSG00000127946
Uniprot IDs		A0A087X004 Q9UI32	B4DK46 O00291
PDB IDs		4BQM 5U0K	2NO2 2QA7 3I00
Enriched GO Terms of Interacting Partners?
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