BBC3 and BCL2L2

Number of citations of the paper that reports this interaction (PubMedID 15694340)
743

Data Source:
HPRD (in vitro)

		BBC3	BCL2L2
Description		BCL2 binding component 3	BCL2 like 2
Image
GO Annotations	Cellular Component	Mitochondrion Lysosome	Mitochondrial Outer Membrane Cytosol Bcl-2 Family Protein Complex
	Molecular Function	Protein Binding ATPase Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity BH Domain Binding Disordered Domain Specific Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Response To Ischemia Spermatogenesis Brain Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Apoptotic Process Sertoli Cell Proliferation Cellular Response To Estradiol Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Amyloid-beta Cellular Response To Glycine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release FOXO-mediated transcription of cell death genes
Drugs			Navitoclax
Diseases
GWAS		Monocyte count ( 27863252) White blood cell count ( 32888494)	Height ( 28552196) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		14 interacting genes: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 FHL5 HGS HSD17B13 MCL1 MYPOP NDUFAB1 UBASH3B WDR5 ZNF438	53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BAX BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35C2 SLC35E3 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53
Entrez ID		27113	599
HPRD ID		16165	03569
Ensembl ID		ENSG00000105327	ENSG00000129473
Uniprot IDs		Q96PG8 Q9BXH1	Q92843
PDB IDs		2M04 4BPI 4BPJ 4BPK 4HNJ 5UUL 6QFM 6QG8 6TQP	1MK3 1O0L 1ZY3 2Y6W 4CIM
Enriched GO Terms of Interacting Partners?
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