BCL2L2 and TCF4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		BCL2L2	TCF4
Description		BCL2 like 2	transcription factor 4
Image
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Cytosol Bcl-2 Family Protein Complex	Chromatin Nucleus Transcription Regulator Complex Beta-catenin-TCF7L2 Complex Beta-catenin-TCF Complex
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity BH Domain Binding Disordered Domain Specific Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TFIIB-class Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Identical Protein Binding Protein Heterodimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Ischemia Spermatogenesis Brain Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Apoptotic Process Sertoli Cell Proliferation Cellular Response To Estradiol Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Amyloid-beta Cellular Response To Glycine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Assembly
Pathways			Myogenesis Myogenesis
Drugs		Navitoclax
Diseases
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 34021172)	Ability to confide in someone ( 29970889) Adult body size ( 32376654) Adventurousness ( 30643258) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Automobile speeding propensity ( 30643258) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Broad depression or schizophrenia ( 30626913) Chin dimples ( 27182965) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal endothelial cell density ( 30894546) Corneal endothelial cell shape (percentage of hexagonally shaped cells) ( 30894546) Corneal hysteresis ( 32716492 30894546) Corneal resistance factor ( 31246245 32716492 30894546) Cutaneous leishmaniasis ( 32830257) Depression ( 33859377 29700475) Diabetic retinopathy ( 21441570) Diastolic blood pressure ( 30224653) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling lonely ( 29500382) Feeling worry ( 29500382) Fuchs's corneal dystrophy ( 28358029 20825314) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431 29313844) Heart rate response to exercise ( 29769521) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intraocular pressure ( 29617998 31798171 29235454) Irritable mood ( 29500382) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Male-pattern baldness ( 28196072) Mental health study participation (completed survey) ( 31263887) Mood instability ( 31168069) Morning person ( 30696823) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Obesity (early onset extreme) ( 23563609) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Pulse pressure ( 30578418) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 28991256 25056061 21926974 19571808 19571811 29483656 22688191 30285260 23974872 23894747) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Self-rated health ( 27864402) Self-reported risk-taking behaviour ( 30271922) Sleep duration (short sleep) ( 30846698) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Surgical recurrence in Crohn's disease ( 33724339) Systolic blood pressure ( 30578418) Tea consumption ( 31046077) Type 2 diabetes ( 30297969) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Walking pace ( 33128006)
Interacting Genes		53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BAX BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35C2 SLC35E3 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53	235 interacting genes: ALKBH4 AQP1 AR ARHGEF1 ARHGEF5 ARL16 ARMC7 ASAP3 ASCL1 ASCL3 ASCL4 ASPSCR1 ATG9A ATOH7 ATP11B ATP6V1B2 BACH1 BANF2 BCAS2 BCL2L15 BCL2L2 C1orf109 C1orf50 C1orf56 CABP5 CALM1 CALM2 CALM3 CASR CBFA2T2 CCNH CDC37 CDC73 CDKN1A CDKN2C CFAP77 CHAF1A CHCHD2 CHIC2 CKS1B CLCNKA COA5 CPNE2 CTBP1 CTIF CTNNB1 DAXX DDX6 DEF6 DENND2B DGCR6 DMRT3 DNTT DUSP23 DUSP29 EFHC1 EIF4E2 EIF4EBP1 EP300 EPB41L3 EPHB6 EXOC8 EXOSC1 FAH FAM110A FAM124B FAM74A4 FERD3L FIGLA FLAD1 FLNA FRS3 GEM GLRX3 GNG10 GOLGA8EP GOLGA8F GORASP2 GTF3C5 GUCD1 HAND2 HAT1 HBP1 HSPB7 ID1 ID2 ID3 ID4 INS JUN JUP KCTD14 KLC3 KLHL32 KLHL38 LASP1 LENG1 LGALS14 LHX4 LIPG LMO1 LMO4 LNPEP LYL1 MAD2L2 MAGOHB MAPKBP1 MARF1 MATN3 MEMO1 MLLT6 MORN4 MRFAP1L1 MRPL10 MSC MSGN1 MSRB3 MVP MYO15B MYO5B MYOD1 NCK2 NDOR1 NECTIN2 NEK6 NEK8 NEU4 NEUROD1 NEUROD4 NEUROG1 NEUROG3 NFAM1 NFKBID NHLH2 NME7 NMUR2 NOL9 NOXA1 NR2C2AP NR4A1 NUDT10 NUDT22 NXPE2 NXT2 OLFM3 ORC4 OSGIN1 OTUD4 PARP1 PATE1 PBLD PIAS2 PIN1 PLEKHN1 POLR1A POLR1C PPIA PPIL1 PPP1R18 PRKAA2 PRKAB2 PRKACA PRKN PSMA1 PSMG2 PTF1A PTGER3 RAB41 RABIF RAD51D RECK RELA REXO1L6P RNF6 RPL18A RSPH14 RUNX1T1 SCOC SCX SDCBP SEC14L4 SETBP1 SGF29 SHFL SIGLEC6 SLC39A13 SLC4A1AP SMAD2 SMCP SMG9 SMOC1 SPATC1L SPG21 SPO11 SRSF2 STAMBPL1 STK16 STX11 SZT2 TAL1 TAL2 TAPBPL TCEA2 TCF23 TCF24 TCF3 TCL1A TLE1 TLE5 TMEM213 TP53 TRAPPC2L TRIM68 TRIML2 TSPOAP1 TSSC4 TSSK3 TSTD2 TTF2 TWIST1 TWIST2 TXNL4B UBASH3B UBE2I UTP23 VPS28 XRCC5 XRCC6 ZDHHC24 ZMYND10 ZNF124 ZNF205-AS1 ZNF417 ZNF587 ZNF688
Entrez ID		599	6925
HPRD ID		03569	03780
Ensembl ID		ENSG00000129473	ENSG00000196628
Uniprot IDs		Q92843	A0A024R2C0 A0A1B0GW91 A0A1B0GWD5 B3KVA4 E9PH57 H3BPJ7 H3BTP3 P15884
PDB IDs		1MK3 1O0L 1ZY3 2Y6W 4CIM	2KWF 6OD3 6OD4 6OD5
Enriched GO Terms of Interacting Partners?
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