FAM50B and KPNA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FAM50B	KPNA4
Description		family with sequence similarity 50 member B	karyopherin subunit alpha 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Midbody Intercellular Bridge	Nucleus Nucleoplasm Cytosol Nuclear Membrane
	Molecular Function	Protein Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Chromatin Organization	NLS-bearing Protein Import Into Nucleus
Pathways			ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) ( 23648065)	Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		49 interacting genes: ACTN2 ADRA1A BICD2 CARD9 CCDC136 CCDC57 CCDC85B CCDC89 CCNC CDR2 DEUP1 FSD2 GFAP GMCL1 GOLGA2 GRIPAP1 HAP1 HOOK2 IKZF1 KASH5 KPNA3 KPNA4 KRT31 KRT34 LDOC1 LZTS1 LZTS2 MID1 MID2 MLH1 NUTF2 PAX6 PDE4DIP PIBF1 PSMB1 RABEP1 TACC1 TBC1D1 TFIP11 TRAF2 TRIM14 TRIM37 TRIM54 UBL5 VAC14 VPS52 WBP4 ZMYND12 ZRANB1	27 interacting genes: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 FAM50B GTF2IRD1 HIF1A HNRNPC HSD3B7 KAT5 KPNB1 MAT2B MTA1 NCBP3 NFE2L2 NTRK3 NUP50 OGT PLAA RAC1 RCC1 RECQL TGM2 WT1
Entrez ID		26240	3840
HPRD ID		16883	04275
Ensembl ID		ENSG00000145945	ENSG00000186432
Uniprot IDs		A0A024QZY3 Q9Y247	O00629
PDB IDs			4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL
Enriched GO Terms of Interacting Partners?
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