PYGO1 and CARM1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
46

Data Source:
BioGRID (two hybrid)

		PYGO1	CARM1
Description		pygopus family PHD finger 1	coactivator associated arginine methyltransferase 1
Image
GO Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Methylated Histone Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Nuclear Receptor Coactivator Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity (H3-R17 Specific) Histone Methyltransferase Activity Lysine-acetylated Histone Binding
	Biological Process	Kidney Development Hematopoietic Progenitor Cell Differentiation Spermatid Nucleus Differentiation Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway	Regulation Of Transcription, DNA-templated Aging Positive Regulation Of Cell Population Proliferation Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Intracellular Estrogen Receptor Signaling Pathway Histone H3-R2 Methylation Histone H3-R17 Methylation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Response To CAMP Regulation Of MRNA Binding Negative Regulation Of Dendrite Development
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Estrogen-dependent gene expression Cytoprotection by HMOX1 Heme signaling
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624)
Interacting Genes		6 interacting genes: BCL9 CARM1 CTNNB1 LENG8 PRMT6 SPTBN1	35 interacting genes: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 DZIP3 ELAVL1 EP300 FLII FOS GRIP1 H3-3A H3-3B H3C1 KDM1A KEAP1 MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PRMT8 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRCAP TP53 UBE2I
Entrez ID		26108	10498
HPRD ID		06064	09158
Ensembl ID		ENSG00000171016	ENSG00000142453
Uniprot IDs		Q9Y3Y4	Q86X55
PDB IDs		2VP7 2VPB 2VPD 2VPE 2VPG	2Y1W 2Y1X 4IKP 5DWQ 5DX0 5DX1 5DX8 5DXA 5DXJ 5U4X 6ARJ 6ARV 6D2L 6DVR 6IZQ 6S70 6S71 6S74 6S77 6S79 6S7A 6S7B 6S7C
Enriched GO Terms of Interacting Partners?
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